Low levels of HIV-1 RNA detected in the cerebrospinal fluid after up to 10 years of suppressive therapy are associated with local immune activation.

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Abstract

Though combination antiretroviral therapy reduces the concentration of HIV-1 RNA in both plasma and cerebrospinal fluid (CSF) below the detection limit of clinical assays, low levels of HIV-1 RNA are frequently detectable in plasma using more sensitive assays. We examined the frequency and magnitude of persistent low-level HIV-1 RNA in CSF and its relation to the central nervous system (CNS) immune activation.

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Journal

Journal ID (iso-abbrev): AIDS

Title: AIDS (London, England)

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1473-5571

ISSN (Print): 0269-9370

Publication date (Electronic): Sep 24 2014

Volume: 28

Issue: 15

Affiliations

[1 ] aDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet and Swedish Institute for Communicable Disease Control, Stockholm, Sweden bDepartment of Neurology, University of California San Francisco, San Francisco, USA cDivision of Biological Chemistry, Biocentre, Innsbruck Medical University, Innsbruck, Austria dDepartment of Infectious Diseases, University of Gothenburg, Gothenburg, Sweden eCentre for Virus Research, Westmead Millennium Institute, Westmead fThe University of Sydney, Sydney, New South Wales, Australia.

Article

Mid ID: NIHMS676544

DOI: 10.1097/QAD.0000000000000400

PMC ID: 4492794

PubMed ID: 25022595

SO-VID: 0063ac46-82bc-45d2-ab18-c780a03502f4

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