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      Comprehensive treatment of deep frostbite of multiple fingers after trauma: A case report

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          Abstract

          BACKGROUND

          Frostbite is becoming increasingly common in urban environments, and severe cases can lead to tissue loss. The treatment goal is to preserve tissue and function; the sooner appropriate treatment is administered, the more tissue can be saved. However, not every patient with deep frostbite seeks medical care promptly.

          CASE SUMMARY

          We report the case of a 73-year-old male patient who was lost in the wilderness for 2 d due to trauma and confusion. He experienced deep frostbite on multiple fingers. Treatment should not be discontinued for patients with deep frostbite who present after the optimum treatment timing. Bullae that no longer form (bloody) blisters within 24 h of aspiration should be removed. Mucopolysaccharide polysulfate cream has clinical value in frostbite treatment. The patient was transferred to Chinese Academy of Medical Sciences and Peking Union Medical College Hospital 12 h after being rescued. The patient had contraindications for thrombolysis, the most effective treatment, due to intracranial hemorrhage and presenting past the optimum treatment timing. We devised a comprehensive treatment plan, which involved delayed use vasodilators and high-pressure oxygen therapy at day 49 post-injury. We experimented with mucopolysaccharide polysulfate cream to treat the frostbite. The aim of the treatment was to safeguard as much tissue as possible. In the end, the fingers that suffered from frostbite were able to be partially preserved.

          CONCLUSION

          The case indicated that patients with severe frostbite who missed the optimal treatment time and had contraindications for thrombolysis could still partially preserve the affected limbs through comprehensive treatment.

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          Most cited references25

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          A controlled trial of a prostacyclin and rt-PA in the treatment of severe frostbite.

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            Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update

            The Wilderness Medical Society convened an expert panel to develop a set of evidence-based guidelines for prevention and treatment of frostbite. We present a review of pertinent pathophysiology. We then discuss primary and secondary prevention measures and therapeutic management. Recommendations are made regarding each treatment and its role in management. These recommendations are graded on the basis of the quality of supporting evidence and balance between the benefits and risks or burdens for each modality according to methodology stipulated by the American College of Chest Physicians. This is an updated version of the guidelines published in 2014.
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              Long-Term Sequelae of Frostbite—A Scoping Review

              Frostbite is tissue damage caused by freezing temperatures and constitutes an important cause of morbidity in cold climate zones and high altitude. The direct effects of sub-zero temperatures lead to tissue freezing, electrolyte shifts and pH alterations, microvascular damage, and eventually to cell death. Upon rewarming, inflammatory reperfusion injury and thrombosis may lead to further tissue damage. Several studies and various case reports show that many patients suffer from long-term sequelae such as vasomotor disturbances (associated with susceptibility to refreezing), and neuropathic and nociceptive pain, as well as damage to skeletal structures. There are still many uncertainties regarding the pathophysiology of these sequelae. It has been shown that the transient receptor potential channel (TRP) family plays a role in cold allodynia. Botulinum Toxin type A (BTX-A) injections have been reported to be beneficial in vasomotor and neuropathic disturbances secondary to frostbite. Epidural sympathetic block has been used for short-term treatment of frostbite induced chronic pain. Furthermore, amitriptyline, gabapentinoids, and duloxetine may have some benefits. Frostbite arthritis clinically resembles regular osteoarthritis. In children there is a risk of epiphyseal cartilage damage leading to bone deformities. Despite some promising therapeutic concepts, the scarcity of data on frostbite long-term sequelae in the literature indicates the need of more in-depth studies of this pathology in all its aspects.
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                Author and article information

                Contributors
                Journal
                World J Clin Cases
                WJCC
                World Journal of Clinical Cases
                Baishideng Publishing Group Inc
                2307-8960
                6 December 2023
                6 December 2023
                : 11
                : 34
                : 8219-8227
                Affiliations
                Department of General Surgery, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, Beijing 100730, China
                Department of General Surgery, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, Beijing 100730, China
                Department of Nursing, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, Beijing 100730, China
                Department of General Surgery, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, Beijing 100730, China
                Department of General Surgery, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, Beijing 100730, China. linguole@ 123456126.com
                Department of General Surgery, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, Beijing 100730, China
                Author notes

                Co-first authors: Xi-Hua Wang and Min Li.

                Co-corresponding authors: Guo-Le Lin and Wei-Nan Liu.

                Author contributions: Wang XH supported the management of this case, collated information for and drafted this report, and managed manuscript revisions; Li M and Cheng Y supported the management of this case and collated information for and drafted this report; Wang XH, Li M, and Cheng Y contributed equally to this work; Lin GL and Liu WN supported in the management of this case and were responsible for revising the manuscript; Wang GJ supported the management of this case; all authors issued final approval for the submission of the manuscript; Wang XH supported the management of this case (was in charge of the care of this case), collated information for and drafted this report, and managed manuscript revisions (revised the manuscript); Li M supported the management of this case (was also in charge of the patient) and collated information for and drafted this report; Wang XH and Li M contributed equally to this work. Wang XH and Li M work together in the same department for a long time. Li M is the leader of this department. They had a graduate advisor in common. Wang XH and Li M are both enterostomal therapists, dedicated to the treatment of wounds and ostomies. In this case, Wang XH and Li M worked together to review the data, and develop and validate treatment plans. They followed this case for 6 mo. Both of them drafted this report. Lin GL is the chief physician and the primary person in charge of the treatment of this case, providing medical guidance and oversight. Liu WN is the deputy chief nurse, an expert in surgical nursing, and the leader of the surgical nursing team, giving guidance and oversight on the nursing plan. In the treatment process of this case, we tried new treatment methods. Lin GL and Liu WN gave us help in the feasibility and effectiveness of the treatment process. They were jointly responsible for the review and revision of this article and the whole process of submission. Lin GL and Liu WN contributed equally to this work.

                Supported by National High Level Hospital Clinical Research Funding, No. 2022-PUMCH-C-005.

                Corresponding author: Guo-Le Lin, MD, PhD, Chief Physician, Doctor, Professor, Department of General Surgery, Peking Union Medical College Hospital and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Road, Dongcheng District, Beijing 100730, China. linguole@ 123456126.com

                Article
                jWJCC.v11.i34.pg8219 88697
                10.12998/wjcc.v11.i34.8219
                10731172
                38130784
                010cbd39-0090-426a-ae99-cd43851aaf1f
                ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

                This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

                History
                : 6 October 2023
                : 27 October 2023
                : 29 November 2023
                Categories
                Case Report

                frostbite,wound care,mucopolysaccharide polysulfate cream,case report

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