Ashlee D. Brunaugh:
ORCID: https://orcid.org/0000-0001-5456-5427
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
MethodologyRole: Project administrationRole: ValidationRole: VisualizationRole: Writing
– original draft
Hyojong Seo: Role: ConceptualizationRole: InvestigationRole: Writing – original draftRole: Writing
– review & editing
Zachary Warnken: Role: ConceptualizationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – original draftRole: Writing – review & editing
Li Ding: Role: InvestigationRole: ValidationRole: Writing – review & editing
Sang Heui Seo: Role: MethodologyRole: Project administrationRole: ResourcesRole: SupervisionRole:
Writing – review & editing
Hugh D. C. Smyth:
ORCID: https://orcid.org/0000-0002-6582-5869
Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole:
ResourcesRole: SupervisionRole: Writing – review & editing
Nitesh Kumar Kunda: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS One
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
11
February
2021
Publication date Collection: 2021
Publication date PMC-release: 11
February
2021
Volume: 16
Issue: 2
Electronic Location Identifier: e0246803
Affiliations
[1
]
Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, University
of Texas at Austin, Austin, Texas, United States of America
[2
]
Laboratory of Influenza Research, College of Veterinary Medicine, Chungnam National
University, Yoseong Gu, Dajeon, Korea
St. John’s University, UNITED STATES
Author notes
Competing Interests: An author (HDCS) of this paper consults for and has equity ownership in Respira Therapeutics,
Nob Hill Therapeutics, Via Therapeutics, LLC, and CloXero Therapeutics, Inc on inhaled
product development. An author of this paper (ADB) is an employee of Via Therapeutics,
LLC and has equity ownership in CloXero Therapeutics, Inc. An author of this paper
(ZW) is an employee of Via Therapeutics, LLC. The terms of this arrangement have been
reviewed and approved by the University of Texas at Austin in accordance with its
poly on objectivity in research. A provisional patent (U.S. Patent Application No.
63/079,674, entitled “Pharmaceutical Compositions of Niclosamide and a Protein,”)
pertaining to the results presented in this paper has been filed by the University
of Texas at Austin. This does not alter our adherence to PLOS ONE policies on sharing
data and materials.
Author information
Article
Publisher ID:
PONE-D-20-37016
DOI: 10.1371/journal.pone.0246803
PMC ID: 7877651
PubMed ID: 33571320
SO-VID: 023162e4-816f-4405-8f08-c05c4aab43ae
Copyright © © 2021 Brunaugh et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: funder-id http://dx.doi.org/10.13039/100000050, National Heart, Lung, and Blood Institute;
Award ID: F31HL146178
Award Recipient
:
ORCID: https://orcid.org/0000-0001-5456-5427
Ashlee D. Brunaugh
Research reported in this publication is supported by the National Heart, Lung and
Blood Institute of the National Institutes of Health under Award Number F31HL146178.
The content reported herein is solely the responsibility of the authors and does not
necessarily represent the official views of the National Institutes of Health. Via
Therapeutics, LLC provided support in the form of salaries for authors ADB and ZW
but did not have any additional role in the study design, data collection and analysis,
decision to publish, or preparation of the manuscript. The specific roles of these
authors are articulated in the ‘author contributions’ section.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Coronaviruses
Subject:
SARS coronavirus
Subject:
SARS CoV 2
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Coronaviruses
Subject:
Biology and Life Sciences
Subject:
Microbiology
Subject:
Medical Microbiology
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Coronaviruses
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Pathogens
Subject:
Microbial Pathogens
Subject:
Viral Pathogens
Subject:
Coronaviruses
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral Pathogens
Subject:
Coronaviruses
Subject:
Medicine and Health Sciences
Subject:
Medical Conditions
Subject:
Infectious Diseases
Subject:
Viral Diseases
Subject:
Covid 19
Subject:
Physical Sciences
Subject:
Materials Science
Subject:
Materials
Subject:
Powders
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Lysozyme
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Lysozyme
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Virus Testing
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Medicine and Health Sciences
Subject:
Public and Occupational Health
Subject:
Preventive Medicine
Subject:
Vaccination and Immunization
Subject:
Antiviral Therapy
Subject:
Physical Sciences
Subject:
Materials Science
Subject:
Materials
Subject:
Mixtures
Subject:
Aerosols
