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      Tongxinluo attenuates atherosclerosis by inhibiting ROS/NLRP3/caspase-1-mediated endothelial cell pyroptosis.

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          Abstract

          Tongxinluo (TXL) is one of the most common traditional Chinese medicines and plays a vital role in treating atherosclerosis (AS). Endothelial cell (EC) pyroptosis plays a crucial role in the development of AS. Previous research revealed the inhibitory function of TXL in EC apoptosis and autophagy. However, whether TXL can inhibit the pyroptosis of ECs has not been determined.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): J Ethnopharmacol
          Title: Journal of ethnopharmacology
          Publisher: Elsevier BV
          ISSN (Electronic): 1872-7573
          ISSN (Print): 0378-8741
          Publication date (Electronic): Mar 25 2023
          Volume: 304
          Affiliations
          [1 ] Beijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China.
          [2 ] Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong'An Road, Xicheng District, Beijing, 100050, PR China.
          [3 ] Hunan University of Traditional Chinese Medicine, 113# Xueshi Road, Yuelu District, Changsha, Hunan, 410208, PR China.
          [4 ] Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, 16 South Street, Dongzhimen Nei, Dongcheng District, Beijing, 100700, China. Electronic address: caoyeying.student@sina.com.
          [5 ] Beijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: zhangqiuyun8202@aliyun.com.
          Article
          Publisher Item ID: S0378-8741(22)01050-9
          DOI: 10.1016/j.jep.2022.116011
          PubMed ID: 36529253
          SO-VID: 039ee3d5-7b47-4ca1-ae4d-7ebd633ed3e9
          History

          Keywords: Tongxinluo,Atherosclerosis,Endothelial cell,Pyroptosis,ROS
          Data availability:
          Keywords: Tongxinluo, Atherosclerosis, Endothelial cell, Pyroptosis, ROS

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