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      Removal of False Blood Vessels Using Shape Based Features and Image Inpainting

      , , ,
      Journal of Sensors
      Hindawi Limited

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          Abstract

          Automated quantification of blood vessels in human retina is the fundamental step in designing any computer-aided diagnosis system for ophthalmic disorders. Detection and analysis of variations in blood vessels can be used to diagnose several ocular diseases like diabetic retinopathy. Diabetic Retinopathy is a progressive vascular disorder caused due to variations in blood vessels of retina. These variations bring different abnormalities like lesions, exudates, and hemorrhages in human retina which make the vessel detection problematic. Therefore, automated retinal analysis is required to cater the effect of lesions while segmenting blood vessels. The proposed framework presents two improved approaches to carry out vessel segmentation in the presence of lesions. The paper mainly aims to extract true vessels by reducing the effect of abnormal structures significantly. First method is a supervised approach which extracts true vessels by performing region based analysis of retinal image, while second method intends to remove lesions before extracting blood vessels by using an inpainting technique. Both methods are evaluated on STARE and DRIVE and on our own database AFIO. Experimental results demonstrate the excellence of the proposed system.

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          Most cited references12

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          Ridge-based vessel segmentation in color images of the retina.

          A method is presented for automated segmentation of vessels in two-dimensional color images of the retina. This method can be used in computer analyses of retinal images, e.g., in automated screening for diabetic retinopathy. The system is based on extraction of image ridges, which coincide approximately with vessel centerlines. The ridges are used to compose primitives in the form of line elements. With the line elements an image is partitioned into patches by assigning each image pixel to the closest line element. Every line element constitutes a local coordinate frame for its corresponding patch. For every pixel, feature vectors are computed that make use of properties of the patches and the line elements. The feature vectors are classified using a kappaNN-classifier and sequential forward feature selection. The algorithm was tested on a database consisting of 40 manually labeled images. The method achieves an area under the receiver operating characteristic curve of 0.952. The method is compared with two recently published rule-based methods of Hoover et al. and Jiang et al. The results show that our method is significantly better than the two rule-based methods (p < 0.01). The accuracy of our method is 0.944 versus 0.947 for a second observer.
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            Locating blood vessels in retinal images by piecewise threshold probing of a matched filter response.

            We describe an automated method to locate and outline blood vessels in images of the ocular fundus. Such a tool should prove useful to eye care specialists for purposes of patient screening, treatment evaluation, and clinical study. Our method differs from previously known methods in that it uses local and global vessel features cooperatively to segment the vessel network. We evaluate our method using hand-labeled ground truth segmentations of 20 images. A plot of the operating characteristic shows that our method reduces false positives by as much as 15 times over basic thresholding of a matched filter response (MFR), at up to a 75% true positive rate. For a baseline, we also compared the ground truth against a second hand-labeling, yielding a 90% true positive and a 4% false positive detection rate, on average. These numbers suggest there is still room for a 15% true positive rate improvement, with the same false positive rate, over our method. We are making all our images and hand labelings publicly available for interested researchers to use in evaluating related methods.
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              An ensemble classification-based approach applied to retinal blood vessel segmentation.

              This paper presents a new supervised method for segmentation of blood vessels in retinal photographs. This method uses an ensemble system of bagged and boosted decision trees and utilizes a feature vector based on the orientation analysis of gradient vector field, morphological transformation, line strength measures, and Gabor filter responses. The feature vector encodes information to handle the healthy as well as the pathological retinal image. The method is evaluated on the publicly available DRIVE and STARE databases, frequently used for this purpose and also on a new public retinal vessel reference dataset CHASE_DB1 which is a subset of retinal images of multiethnic children from the Child Heart and Health Study in England (CHASE) dataset. The performance of the ensemble system is evaluated in detail and the incurred accuracy, speed, robustness, and simplicity make the algorithm a suitable tool for automated retinal image analysis.
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                Author and article information

                Journal
                Journal of Sensors
                Journal of Sensors
                Hindawi Limited
                1687-725X
                1687-7268
                2015
                2015
                : 2015
                :
                : 1-13
                Article
                10.1155/2015/839894
                06a82742-62b5-40a2-8afb-e8ffd498c6d6
                © 2015

                http://creativecommons.org/licenses/by/3.0/

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