Valve-Related Hemodynamics Mediate Human Bicuspid Aortopathy: Insights From Wall Shear Stress Mapping.

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Abstract

Suspected genetic causes for extracellular matrix (ECM) dysregulation in the ascending aorta in patients with bicuspid aortic valves (BAV) have influenced strategies and thresholds for surgical resection of BAV aortopathy. Using 4-dimensional (4D) flow cardiac magnetic resonance imaging (CMR), we have documented increased regional wall shear stress (WSS) in the ascending aorta of BAV patients.

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Author and article information

Journal

Journal ID (iso-abbrev): J. Am. Coll. Cardiol.

Title: Journal of the American College of Cardiology

Publisher: Elsevier BV

ISSN (Electronic): 1558-3597

ISSN (Print): 0735-1097

Publication date (Electronic): Aug 25 2015

Volume: 66

Issue: 8

Affiliations

[1 ] Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada.

[2 ] Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

[3 ] Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands.

[4 ] Division of Cardiac Surgery, Department of Surgery, Bluhm Cardiovascular Institute, Northwestern University, Chicago, Illinois.

[5 ] Division of Cardiology, Department of Medicine, Bluhm Cardiovascular Institute, Northwestern University, Chicago, Illinois.

[6 ] Division of Cardiac Surgery, Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, Canada.

[7 ] Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, Illinois.

[8 ] Division of Cardiac Surgery, Department of Surgery, Bluhm Cardiovascular Institute, Northwestern University, Chicago, Illinois; Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Chicago, Illinois.

[9 ] Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada; Division of Cardiac Surgery, Department of Surgery, Bluhm Cardiovascular Institute, Northwestern University, Chicago, Illinois. Electronic address: paul.fedak@gmail.com.

Article

Publisher Item ID: S0735-1097(15)04223-0 Mid ID: NIHMS706747

DOI: 10.1016/j.jacc.2015.06.1310

PMC ID: 4545965

PubMed ID: 26293758

SO-VID: 0765f77f-68ca-4563-9bd8-60f74bd6a4f0

History

Keywords: aneurysm,imaging,remodeling

Data availability:

Keywords: aneurysm, imaging, remodeling

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