For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
2
views
43
references
 Top references
cited by
25
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      635
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Drug delivery to retinal photoreceptors

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Highlights

          • •

            Routes of administration to retinal photoreceptors.

          • •

            The blood–retinal barrier as a challenge for photoreceptor drug delivery.

          • •

            Review of nanoparticle drug delivery systems used for intraocular applications.

          • •

            Perspectives for topical drug delivery to the retina.

          Abstract

          The photoreceptors of the retina are afflicted by diseases that still often lack satisfactory treatment options. Although suitable drugs might be available in some cases, the delivery of these compounds into the eye and across the blood–retinal barrier remains a significant challenge for therapy development. Here, we review the routes of drug administration to the retina and highlight different options for drug delivery to the photoreceptor cells.

          Related collections

          Most cited references43

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Brain and Retinal Pericytes: Origin, Function and Role

          Andrea Trost, Simona Lange, Falk Schroedl … (2016)
          Pericytes are specialized mural cells located at the abluminal surface of capillary blood vessels, embedded within the basement membrane. In the vascular network these multifunctional cells fulfil diverse functions, which are indispensable for proper homoeostasis. They serve as microvascular stabilizers, are potential regulators of microvascular blood flow and have a central role in angiogenesis, as they for example regulate endothelial cell proliferation. Furthermore, pericytes, as part of the neurovascular unit, are a major component of the blood-retina/brain barrier. CNS pericytes are a heterogenic cell population derived from mesodermal and neuro-ectodermal germ layers acting as modulators of stromal and niche environmental properties. In addition, they display multipotent differentiation potential making them an intriguing target for regenerative therapies. Pericyte-deficiencies can be cause or consequence of many kinds of diseases. In diabetes, for instance, pericyte-loss is a severe pathological process in diabetic retinopathy (DR) with detrimental consequences for eye sight in millions of patients. In this review, we provide an overview of our current understanding of CNS pericyte origin and function, with a special focus on the retina in the healthy and diseased. Finally, we highlight the role of pericytes in de- and regenerative processes.
          Article 0 comments Cited 95 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            UV and near-IR triggered release from polymeric nanoparticles.

            Osayimwense Edigin, Marleen Sermsakdi, Janna N Fomina … (2010)
            A new light-sensitive polymer containing multiple light-sensitive triggering groups along the backbone and incorporating a quinone-methide self-immolative moiety was developed and formulated into nanoparticles encapsulating a model pharmaceutical Nile Red. Triggered burst release of the payload upon irradiation and subsequent degradation of the nanoparticles were observed. This system is designed to be versatile where the triggering group can be sensitive to a number of wavelengths.
            Article 0 comments Cited 83 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Topical and systemic drug delivery to the posterior segments.

              Dennis P M Hughes, Joan Chang, O Olejnik … (2005)
              The posterior segments of the eye are exquisitely protected from the external environment. This poses unique and fairly challenging hurdles for drug delivery. It is somewhat dogmatic that topical ocular delivery is insufficient to achieve therapeutic drug levels in the posterior segments. However, some drugs are currently challenging this dogma. In this review we investigate the constraints and challenges of drug delivery to the posterior segment. Additionally, we outline several potential absorption pathways that may potentially be exploited to deliver drug to the back of the eye. Data on several compounds that achieve therapeutic posterior segment concentrations after topical dosing is presented. Finally, the issues surrounding systemic delivery to the posterior segment are reviewed.
              Article 0 comments Cited 64 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                François Paquet-Durand
                Journal
                Journal ID (nlm-ta): Drug Discov Today
                Journal ID (iso-abbrev): Drug Discov. Today
                Title: Drug Discovery Today
                Publisher: Elsevier Science Ltd. ;, Distributed by Virgin Mailing and Distribution
                ISSN (Print): 1359-6446
                ISSN (Electronic): 1878-5832
                Publication date PMC-release: 1 August 2019
                Publication date (Print): August 2019
                Volume: 24
                Issue: 8
                Pages: 1637-1643
                Affiliations
                [1 ]InoCure s.r.o., Prague, Czech Republic
                [2 ]Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Ophthalmology, Lund, Sweden
                [3 ]2-BBB Medicines BV, Leiden, The Netherlands
                [4 ]Faculty of Medicine, University of Iceland, Reykjavík, Iceland
                [5 ]Department of Life Sciences, University of Modena and Reggio Emilia, Italy
                [6 ]Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavík, Iceland
                [7 ]Institute for Ophthalmic Research, University of Tübingen, Germany
                Author notes
                Article
                Publisher ID: S1359-6446(18)30511-7
                DOI: 10.1016/j.drudis.2019.03.004
                PMC ID: 6715772
                PubMed ID: 30877076
                SO-VID: 07accd09-4c07-4514-9082-94426e910c14
                Copyright © © 2019 The Authors
                License:

                This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

                History
                Categories
                Subject: Article

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine

                Comments

                Comment on this article

                scite_

                Similar content635

                See all similar

                Cited by25

                See all cited by

                Most referenced authors487

                See all reference authors