Effect of Botulinum Toxin Type A on TGF-β/Smad Pathway Signaling: Implications for Silicone-Induced Capsule Formation.

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Abstract

One of the most serious complications of breast surgery using implants is capsular contracture. Several preventive treatments have been introduced; however, the mechanism of capsule formation has not been resolved completely. The authors previously identified negative effects of botulinum toxin type A on capsule formation, expression of transforming growth factor (TGF)-β1, and differentiation of fibroblasts into myofibroblasts. Thus, the authors investigated how to prevent capsule formation by using botulinum toxin type A, particularly by means of TGF-β1 signaling, in human fibroblasts.

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Journal

Journal ID (iso-abbrev): Plast. Reconstr. Surg.

Title: Plastic and reconstructive surgery

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1529-4242

ISSN (Print): 0032-1052

Publication date (Electronic): Nov 2016

Volume: 138

Issue: 5

Affiliations

[1 ] Daejeon, Republic of Korea From the Departments of Plastic Surgery, Anatomy, General Surgery, and Dermatology and the Brain Research Institute, Collage of Medicine, Chungnam National University.

Article

DOI: 10.1097/PRS.0000000000002625

PubMed ID: 27391832

SO-VID: 07c09200-eeab-4f62-944a-110e72c9a611

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