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Abstract
Weight loss can be achieved through a variety of modalities, but long-term maintenance
of lost weight is much more challenging. Obesity interventions typically result in
early weight loss followed by a weight plateau and progressive regain. This review
describes current understanding of the biological, behavioral, and environmental factors
driving this near-ubiquitous body weight trajectory and the implications for long-term
weight management. Treatment of obesity requires ongoing clinical attention and weight
maintenance-specific counseling to support sustainable healthful behaviors and positive
weight regulation.