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      An Introduction to the Measurement of the Cerebral Oxygen Uptake Rate by Inhalation of 15O 2: Analysis of the Contribution of 15O 2 and H 2 I5O in Brain Radioactivity

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          Abstract

          This paper introduces a model for the computation of the regional cerebral metabolic rate of oxygen from the data of cerebral regional radioactivity collected after inhalation of <sup>15</sup>O<sub>2</sub>. A method was devised for the differential determination of the respective contribution of radiooxygen and of radiowater in the inflow and the outflow of radioactivity in the brain after or during such on inhalation. The results demonstrate the feasability of such a model and outline some of the methodological prerequisites to be taken into account in the numerical analysis of the data.

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          Author and article information

          Journal
          Journal ID (publisher-id): ENE
          Journal ID (nlm-ta): Eur Neurol
          Journal ID (doi): 10.1159/issn.0014-3022
          Title: European Neurology
          Publisher: S. Karger AG
          ISBN: 978-3-8055-3412-3
          ISBN: 978-3-8055-8779-2
          ISSN (Print): 0014-3022
          ISSN (Electronic): 1421-9913
          Publication date Subscription-year: 1981
          Publication date (Print): 1981
          Publication date (Electronic): 29 January 2008
          Volume: 20
          Issue: 3
          Pages: 207-214
          Affiliations
          aNational Foundation for Scientific Research, Cyclotron Research Center, University of Liège, Liège, Belgium; bDivision of Radiation Sciences, Edward Mallinckrodt Institute of Radiology, Department of Neurology and of Neurological Surgery, and c Biomedical Computing Laboratory, Washington University School of Medicine, St. Louis, Mo., USA
          Article
          Publisher ID: 115235 Other ID: Eur Neurol 1981;20:207–214
          DOI: 10.1159/000115235
          PubMed ID: 7262119
          SO-VID: 0ba4e985-0f19-41c0-98ac-be5e9c6ef637
          Copyright © © 1981 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Page count
          Pages: 8
          Categories
          Subject: Deoxyglucose Uptake and Oxygen Consumption: a Metabolic Approach to Cerebral Function

          ScienceOpen disciplines: Geriatric medicine,Neurology,Cardiovascular Medicine,Neurosciences,Clinical Psychology & Psychiatry,Public health
          Keywords: Model,Brain, 15O2 ,Water metabolism
          Data availability:
          ScienceOpen disciplines: Geriatric medicine, Neurology, Cardiovascular Medicine, Neurosciences, Clinical Psychology & Psychiatry, Public health
          Keywords: Model, Brain, 15O2 , Water metabolism

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