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      Effect of change in vaccine schedule on pertussis epidemiology in France: a modelling and serological study.

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          Abstract

          In April-May, 2013, France modified its pertussis vaccination schedule, which uses the acellular pertussis vaccine, from three primary doses at 2, 3, and 4 months of age and a first booster at 16-18 months of age (former schedule) to two primary doses at 2 and 4 months of age and a first booster at 11 months of age (new schedule). We aimed to assess the subsequent effect of the vaccine schedule change on pertussis epidemiology in France.

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          Author and article information

          Journal
          Lancet Infect Dis
          The Lancet. Infectious diseases
          Elsevier BV
          1474-4457
          1473-3099
          February 2022
          : 22
          : 2
          Affiliations
          [1 ] Mathematic Modelling of Infectious Diseases Unit, UMR 2000, CNRS, Institut Pasteur, Université de Paris, Paris, France; Direction des Maladies Infectieuses, Santé publique France, Saint Maurice, France.
          [2 ] Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Université de Paris, Paris, France; National Reference Center for Whooping Cough and Other Bordetella Infections, Institut Pasteur, Université de Paris, Paris, France.
          [3 ] Unité des Infections Respiratoires et Vaccination, Santé publique France, Saint Maurice, France.
          [4 ] Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Université de Paris, Paris, France; Department of General Paediatrics and Paediatric Infectious Diseases, Necker-Enfants malades University Hospital, Université de Paris, AP-HP, Paris, France.
          [5 ] Laboratoire Cerba, St Ouen l'Aumône, France.
          [6 ] Laboratoire Eurofins-Biomnis, Lyon, France.
          [7 ] Invasive Bacterial Infection and National Reference Center for Meningococci and Haemophilus influenzae, Institut Pasteur, Université de Paris, Paris, France.
          [8 ] Mathematic Modelling of Infectious Diseases Unit, UMR 2000, CNRS, Institut Pasteur, Université de Paris, Paris, France; Department of Genetics, University of Cambridge, UK.
          [9 ] Mathematic Modelling of Infectious Diseases Unit, UMR 2000, CNRS, Institut Pasteur, Université de Paris, Paris, France.
          [10 ] Biodiversity and Epidemiology of Bacterial Pathogens, Institut Pasteur, Université de Paris, Paris, France; National Reference Center for Whooping Cough and Other Bordetella Infections, Institut Pasteur, Université de Paris, Paris, France; Department of General Paediatrics and Paediatric Infectious Diseases, Necker-Enfants malades University Hospital, Université de Paris, AP-HP, Paris, France. Electronic address: julie.toubiana@aphp.fr.
          Article
          S1473-3099(21)00267-X
          10.1016/S1473-3099(21)00267-X
          34672963
          0c761761-eab2-49ed-af55-24290403400d
          Copyright © 2022 Elsevier Ltd. All rights reserved.
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