NOX2-derived ROS-mediated surface translocation of BLT1 is essential for exocytosis in human eosinophils induced by LTB4.

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Abstract

Leukotriene B4 (LTB4) is a proinflammatory lipid mediator that elicits eosinophil exocytosis, leading to allergic inflammation. However, the detailed intracellular signaling mechanisms of eosinophil exocytosis induced by LTB4 are poorly understood. Herein, we report that NADPH oxidase (NOX)2-derived reactive oxygen species (ROS)-mediated BLT1 migration to the cell surface is required for exocytosis in human eosinophils induced by LTB4.

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Journal

Journal ID (iso-abbrev): Int. Arch. Allergy Immunol.

Title: International archives of allergy and immunology

Publisher: S. Karger AG

ISSN (Electronic): 1423-0097

ISSN (Print): 1018-2438

Publication date (Electronic): 2014

Volume: 165

Issue: 1

Affiliations

[1 ] Department of Environmental Medical Biology, Yonsei University College of Medicine, Seoul, Republic of Korea.

Article

Publisher Item ID: 000366277

DOI: 10.1159/000366277

PubMed ID: 25323785

SO-VID: 0d194e06-8e8d-4995-97b5-badf082a566f

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