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      The role of HLA-DRB1 alleles on susceptibility of Chinese patients with anti-GBM disease

      , , ,
      Clinical Immunology
      Elsevier BV

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          Abstract

          Anti-glomerular basement membrane (GBM) disease, a rare autoimmune disorder, is associated with HLA-DR15 genotype in Caucasian and Japanese populations. But the distribution of HLA-DRB1 alleles in Chinese patients with anti-GBM disease and their association with clinical characteristics of anti-GBM disease are to be determined. The present study analyzed the HLA-DRB1 alleles by sequence based typing in 44 Chinese patients with anti-GBM disease and 200 healthy controls. The effects of DRB1 alleles on susceptibility to anti-GBM disease were examined by a relative predispositional effects (RPEs) method. The clinical and pathological data of the patients were collected and analyzed. The DRB1*1501 allele was significantly associated with anti-GBM disease (p=1.597 x 10(-7)). The RPEs test also showed a significant increased frequency of DRB1*0404 in anti-GBM disease (p=0.037). Interestingly, the patients with DRB1*1501 or 0404 had more crescent formation in glomeruli than those without the two alleles (p=0.021). But the DRB1*0404 was rare in both patients and control groups, which indicates that the importance of the *0404 allele is limited in anti-GBM disease. We conclude that the HLA-DRB1*1501 allele is a genetic marker for susceptibility to anti-GBM disease.

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          Author and article information

          Journal
          Clinical Immunology
          Clinical Immunology
          Elsevier BV
          15216616
          November 2009
          November 2009
          : 133
          : 2
          : 245-250
          Article
          10.1016/j.clim.2009.07.005
          19654074
          0e3d17b4-5147-458e-a373-0b2899501823
          © 2009

          https://www.elsevier.com/tdm/userlicense/1.0/

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