Gut microbiome and osteoporosis

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Abstract

Osteoporosis (OP) is a chronic metabolic bone disease characterized by the decrease of bone tissue per unit volume under the combined action of genetic and environmental factors, which leads to the decrease of bone strength, makes the bone brittle, and raises the possibility of bone fracture. However, the exact mechanism that determines the progression of OP remains to be underlined. There are hundreds of trillions of symbiotic bacteria living in the human gut, which have a mutually beneficial symbiotic relationship with the human body that helps to maintain human health. With the development of modern high-throughput sequencing (HTS) platforms, there has been growing evidence that the gut microbiome may play an important role in the programming of bone metabolism. In the present review, we discuss the potential mechanisms of the gut microbiome in the development of OP, such as alterations of bone metabolism, bone mineral absorption, and immune regulation. The potential of gut microbiome-targeted strategies in the prevention and treatment of OP was also evaluated.

Cite this article: Bone Joint Res 2020;9(8):524–530.

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Most cited references 42

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Author and article information

Contributors

Sucheng Li: Role: Orthopaedic Surgeon

Yubo Mao: Role: Orthopaedic Surgeon

Feng Zhou: Role: Orthopaedic Surgeon

Huilin Yang: Role: Orthopaedic Surgeon

Qin Shi: Role: Professor

Bin Meng: Role: Orthopaedic Surgeon

Journal

Journal ID (nlm-ta): Bone Joint Res

Journal ID (iso-abbrev): Bone Joint Res

Journal ID (publisher-id): bjr

Title: Bone & Joint Research

Publisher: The British Editorial Society of Bone & Joint Surgery (London )

ISSN (Electronic): 2046-3758

Publication date Collection: August 2020

Publication date (Electronic): 2 August 2020

Volume: 9

Issue: 8

Pages: 524-530

Affiliations

[1 ]org-divisionDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University , Suzhou, China

Author notes

Correspondence should be sent to Bin Meng. E-mail: mengbinspine@ 123456163.com

S. Li and Y. Mao contributed equally to this work.

Article

Publisher ID: BJR-9-524

DOI: 10.1302/2046-3758.98.BJR-2020-0089.R1

PMC ID: 7468557

PubMed ID: 32922760

SO-VID: 127bb625-90db-42c9-a09a-02db0875396e

License:

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND 4.0) licence, which permits the copying and redistribution of the work only, and provided the original author and source are credited.