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      NAFLD and diabetes mellitus

      , ,
      Nature Reviews Gastroenterology & Hepatology
      Springer Nature

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          Abstract

          The liver constitutes a key organ in systemic metabolism, contributing substantially to the development of insulin resistance and type 2 diabetes mellitus (T2DM). The mechanisms underlying these processes are not entirely understood, but involve hepatic fat accumulation, alterations of energy metabolism and inflammatory signals derived

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          Most cited references150

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          Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

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            EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease.

            (2016)
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              Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

              Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown etiology that varies in prevalence among ethnic groups. To identify genetic variants contributing to differences in hepatic fat content, we performed a genome-wide association scan of nonsynonymous sequence variations (n=9,229) in a multiethnic population. An allele in PNPLA3 (rs738409; I148M) was strongly associated with increased hepatic fat levels (P=5.9×10−10) and with hepatic inflammation (P=3.7×10−4). The allele was most common in Hispanics, the group most susceptible to NAFLD; hepatic fat content was > 2-fold higher in PNPLA3-148M homozygotes than in noncarriers. Resequencing revealed another allele associated with lower hepatic fat content in African-Americans, the group at lowest risk of NAFLD. Thus, variation in PNPLA3 contributes to ethnic and inter-individual differences in hepatic fat content and susceptibility to NAFLD.
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                Author and article information

                Journal
                Nature Reviews Gastroenterology & Hepatology
                Nat Rev Gastroenterol Hepatol
                Springer Nature
                1759-5045
                1759-5053
                October 12 2016
                October 12 2016
                : 14
                : 1
                : 32-42
                Article
                10.1038/nrgastro.2016.147
                27729660
                13620020-dca7-4b24-b027-aaec9a43618c
                © 2016
                History

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