Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population

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Abstract

Background

The present study evaluated the predictive ability of five known “best” obesity and lipid-related parameters, including body mass index (BMI), waist-to-height ratio (WHtR), triglyceride-to-high-density-lipoprotein-cholesterol (TG/HDL-C), lipid accumulation product (LAP) and visceral adiposity index (VAI), in identifying metabolic syndrome (MetS) in Chinese elderly population.

Methods

A total of 6722 elderly Chinese subjects (≥60 years) were recruited into our community-based cross-sectional study from April 2015 to July 2017. The anthropometrics, blood pressure, fasting plasma glucose, blood lipid profiles, family history and health-related behaviours were assessed.

Results

The prevalence of MetS was 40.4% (32.5% in males and 47.2% in females). With the increase in the number of MetS components (from 0 to 5), all the five parameters showed an increase trend in both genders (all P for trend < 0.001). According to receiver operating characteristic curve (ROC) analyses, all the five parameters performed high predictive value in identifying MetS. The statistical significance of the areas under the curves (AUCs) differences suggested that the AUCs of LAP were the greatest among others in both genders (AUCs were 0.897 in males and 0.875 in females). The optimal cut-off values of LAP were 26.35 in males and 31.04 in females. After adjustment for potentially confounding factors, LAP was strongly associated with the odds of having MetS in both genders, and ORs for MetS increased across quartiles using multivariate logistic regression analysis ( P < 0.001).

Conclusion

LAP appeared to be a superior parameter for predicting MetS in both Chinese elderly males and females, better than VAI, TG/HDL-C, WHtR and BMI.

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Most cited references 31

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Metabolic syndrome and risk of cardiovascular disease: a meta-analysis.

Andrea Galassi, Kristi Reynolds, Jiang Ping He (2006)

The use of different definitions of the metabolic syndrome has led to inconsistent results on the association between the metabolic syndrome and risk of cardiovascular disease. We examined the association between the metabolic syndrome and risk of cardiovascular disease. A MEDLINE search (1966-April 2005) was conducted to identify prospective studies that examined the association between the metabolic syndrome and risk of cardiovascular disease. Information on sample size, participant characteristics, metabolic syndrome definition, follow-up duration, and endpoint assessment was abstracted. Data from 21 studies met the inclusion criteria and were included. Individuals with the metabolic syndrome, compared to those without, had an increased mortality from all causes (relative risk [RR] 1.35; 95% confidence interval [CI], 1.17-1.56) and cardiovascular disease (RR 1.74; 95% CI, 1.29-2.35); as well as an increased incidence of cardiovascular disease (RR 1.53; 95% CI, 1.26-1.87), coronary heart disease (RR 1.52; 95% CI, 1.37-1.69) and stroke (RR 1.76; 95% CI, 1.37-2.25). The relative risk of cardiovascular disease associated with the metabolic syndrome was higher in women compared with men and higher in studies that used the World Health Organization definition compared with studies that used the Adult Treatment Panel III definition. This analysis strongly suggests that the metabolic syndrome is an important risk factor for cardiovascular disease incidence and mortality, as well as all-cause mortality. The detection, prevention, and treatment of the underlying risk factors of the metabolic syndrome should become an important approach for the reduction of the cardiovascular disease burden in the general population.

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Metabolic Syndrome and Incident Diabetes

Earl S. Ford, Chaoyang Li, Naveed Sattar (2008)

OBJECTIVE—Our objective was to perform a quantitative review of prospective studies examining the association between the metabolic syndrome and incident diabetes. RESEARCH DESIGN AND METHODS—Using the title terms “diabetes” and “metabolic syndrome” in PubMed, we searched for articles published since 1998. RESULTS—Based on the results from 16 cohorts, we performed a meta-analysis of estimates of relative risk (RR) and incident diabetes. The random-effects summary RRs were 5.17 (95% CI 3.99–6.69) for the 1999 World Health Organization definition (ten cohorts); 4.45 (2.41–8.22) for the 1999 European Group for the Study of Insulin Resistance definition (four cohorts); 3.53 (2.84–4.39) for the 2001 National Cholesterol Education Program definition (thirteen cohorts); 5.12 (3.26–8.05) for the 2005 American Heart Association/National Heart, Lung, and Blood Institute definition (five cohorts); and 4.42 (3.30–5.92) for the 2005 International Diabetes Federation definition (nine cohorts). The fixed-effects summary RR for the 2004 National Heart, Lung, and Blood Institute/American Heart Association definition was 5.16 (4.43–6.00) (six cohorts). Higher number of abnormal components was strongly related to incident diabetes. Compared with participants without an abnormality, estimates of RR for those with four or more abnormal components ranged from 10.88 to 24.4. Limited evidence suggests fasting glucose alone may be as good as metabolic syndrome for diabetes prediction. CONCLUSIONS—The metabolic syndrome, however defined, has a stronger association with incident diabetes than that previously demonstrated for coronary heart disease. Its clinical value for diabetes prediction remains uncertain.

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Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction

Marco Calogero Amato, Carla Giordano (2014)

The Visceral Adiposity Index (VAI) has recently proven to be an indicator of adipose distribution and function that indirectly expresses cardiometabolic risk. In addition, VAI has been proposed as a useful tool for early detection of a condition of cardiometabolic risk before it develops into an overt metabolic syndrome. The application of the VAI in particular populations of patients (women with polycystic ovary syndrome, patients with acromegaly, patients with NAFLD/NASH, patients with HCV hepatitis, patients with type 2 diabetes, and general population) has produced interesting results, which have led to the hypothesis that the VAI could be considered a marker of adipose tissue dysfunction. Unfortunately, in some cases, on the same patient population, there is conflicting evidence. We think that this could be mainly due to a lack of knowledge of the application limits of the index, on the part of various authors, and to having applied the VAI in non-Caucasian populations. Future prospective studies could certainly better define the possible usefulness of the VAI as a predictor of cardiometabolic risk.

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Author and article information

Contributors

Lei Zhang: zhanglei37@sina.com

Baocheng Liu: baochliumed@126.com

Journal

Journal ID (nlm-ta): Lipids Health Dis

Journal ID (iso-abbrev): Lipids Health Dis

Title: Lipids in Health and Disease

Publisher: BioMed Central (London )

ISSN (Electronic): 1476-511X

Publication date (Electronic): 20 December 2018

Publication date PMC-release: 20 December 2018

Publication date Collection: 2018

Volume: 17

Electronic Location Identifier: 289

Affiliations

[1 ]ISNI 0000 0001 2372 7462, GRID grid.412540.6, Shanghai Innovation Center of TCM Health Service, , Shanghai University of Traditional Chinese Medicine, ; Shanghai, 201203 China

[2 ]ISNI 0000 0001 2372 7462, GRID grid.412540.6, School of Rehabilitation Science, , Shanghai University of Traditional Chinese Medicine, ; Shanghai, 201203 China

[3 ]Zhangjiang Community Health Service Center of Pudong New District, Shanghai, 201210 China

[4 ]GRID grid.411480.8, Institute of Digestive Diseases, China-Canada Center of Research for Digestive Diseases (ccCRDD), , Longhua Hospital, Shanghai University of Traditional Chinese Medicine, ; Shanghai, 200032 China

Article

Publisher ID: 927

DOI: 10.1186/s12944-018-0927-x

PMC ID: 6302378

PubMed ID: 30572889

SO-VID: 154ff345-5dca-4cf3-9e5a-60f2685868ab

License:

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

History

Date received : 12 July 2018

Date accepted : 26 November 2018

Funding

Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;

Award ID: No. 816220108030

Award ID: No. 81603411

Award ID: No. 81573814

Award Recipient : Guang Ji Lei Zhang

Funded by: FundRef http://dx.doi.org/10.13039/501100002858, China Postdoctoral Science Foundation;

Award ID: No. 2018M630465

Custom metadata

ScienceOpen disciplines: Biochemistry

Keywords: metabolic syndrome,obesity and lipid-related parameters,chinese elderly population,lipid accumulation product,visceral adiposity index,triglyceride-to-high-density-lipoprotein-cholesterol,waist-to-height ratio,body mass index

Data availability:

ScienceOpen disciplines: Biochemistry

Keywords: metabolic syndrome, obesity and lipid-related parameters, chinese elderly population, lipid accumulation product, visceral adiposity index, triglyceride-to-high-density-lipoprotein-cholesterol, waist-to-height ratio, body mass index

Obesity and lipid-related parameters for predicting metabolic syndrome in Chinese elderly population

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Abstract

Background

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Conclusion

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Karger: Nutrition and Dietetics

Most cited references 31

Metabolic syndrome and risk of cardiovascular disease: a meta-analysis.

Metabolic Syndrome and Incident Diabetes

Visceral Adiposity Index: An Indicator of Adipose Tissue Dysfunction

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