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Abstract
Macrophagic myofasciitis and chronic fatigue syndrome are severely disabling conditions
which may be caused by adverse reactions to aluminium-containing adjuvants in vaccines.
While a little is known of disease aetiology both conditions are characterised by
an aberrant immune response, have a number of prominent symptoms in common and are
coincident in many individuals. Herein, we have described a case of vaccine-associated
chronic fatigue syndrome and macrophagic myofasciitis in an individual demonstrating
aluminium overload. This is the first report linking the latter with either of these
two conditions and the possibility is considered that the coincident aluminium overload
contributed significantly to the severity of these conditions in this individual.
This case has highlighted potential dangers associated with aluminium-containing adjuvants
and we have elucidated a possible mechanism whereby vaccination involving aluminium-containing
adjuvants could trigger the cascade of immunological events which are associated with
autoimmune conditions including chronic fatigue syndrome and macrophagic myofasciitis.