Blog
About

11
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Nuclear retinoid receptors and the transcription of retinoid-target genes.

      Genes

      metabolism, Ubiquitin, genetics, drug effects, Transcription, Genetic, pharmacology, Retinoids, Receptors, Retinoic Acid, Proteasome Endopeptidase Complex, Phosphorylation, Multienzyme Complexes, Models, Genetic, Humans, Gene Expression Regulation, Cysteine Endopeptidases, Binding Sites, Base Sequence, Animals

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The pleiotropic effects of retinoids are mediated by nuclear retinoid receptors (RARs and RXRs) which are ligand-activated transcription factors. In response to retinoid binding, RAR/RXR heterodimers undergo major conformational changes and orchestrate the transcription of specific gene networks, through binding to specific DNA response elements and recruiting cofactor complexes that act to modify local chromatin structure and/or engage the basal transcription machinery. Then the degradation of RARs and RXRs by the ubiquitin-proteasome controls the magnitude and the duration of the retinoid response. RARs and RXRs also integrate a variety of signaling pathways through phosphorylation events which cooperate with the ligand for the control of retinoid-target genes transcription. These different modes of regulation reveal unexpected levels of complexity in the dynamics of retinoid-dependent transcription.

          Related collections

          Author and article information

          Journal
          10.1016/j.gene.2003.12.005
          15019979

          Comments

          Comment on this article