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      The DNA-damage response in human biology and disease.

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      Nature

      Springer Nature

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          Abstract

          The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.

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          Author and article information

          Affiliations
          [1 ] The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. s.jackson@gurdon.cam.ac.uk
          Journal
          Nature
          Nature
          Springer Nature
          1476-4687
          0028-0836
          Oct 22 2009
          : 461
          : 7267
          nature08467 UKMS31305
          10.1038/nature08467
          2906700
          19847258

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