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The DNA-damage response in human biology and disease.

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Nature

Springer Nature

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      Abstract

      The prime objective for every life form is to deliver its genetic material, intact and unchanged, to the next generation. This must be achieved despite constant assaults by endogenous and environmental agents on the DNA. To counter this threat, life has evolved several systems to detect DNA damage, signal its presence and mediate its repair. Such responses, which have an impact on a wide range of cellular events, are biologically significant because they prevent diverse human diseases. Our improving understanding of DNA-damage responses is providing new avenues for disease management.

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      Author and article information

      Affiliations
      [1 ] The Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. s.jackson@gurdon.cam.ac.uk
      Journal
      Nature
      Nature
      Springer Nature
      1476-4687
      0028-0836
      Oct 22 2009
      : 461
      : 7267
      19847258
      nature08467
      10.1038/nature08467
      2906700
      UKMS31305

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