Comparison of three tests for latent tuberculosis infection in high-risk people in the USA: an observational cohort study.

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Abstract

Treatment of latent tuberculosis infection is an important strategy to prevent tuberculosis disease. In the USA, three tests are used to identify latent tuberculosis infection: the tuberculin skin test (TST) and two IFN-γ release assays (T-SPOT.TB and QuantiFERON). To our knowledge, few large studies have compared all three tests among people at high risk of latent tuberculosis infection or progression to tuberculosis disease. We aimed to assess test agreement between IFN-γ release assays and TST to provide guidance on their use in important risk groups.

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Journal

Journal ID (iso-abbrev): Lancet Infect Dis

Title: The Lancet. Infectious diseases

Publisher: Elsevier BV

ISSN (Electronic): 1474-4457

ISSN (Print): 1473-3099

Publication date (Electronic): January 2022

Volume: 22

Issue: 1

Affiliations

[1 ] Division of Tuberculosis Elimination, US Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: gtb9@cdc.gov.

[2 ] Division of Tuberculosis Elimination, US Centers for Disease Control and Prevention, Atlanta, GA, USA.

[3 ] TB Control Program, Public Health-Seattle and King County, Seattle, WA, USA.

[4 ] Division of Infectious Diseases and International Health, Department of Medicine, Duke University Medical Center, Durham, NC, USA.

[5 ] Tuberculosis Control Branch, Division of Communicable Disease Control, Center for Infectious Diseases, California Department of Public Health, Richmond, CA, USA.

[6 ] Division of Global Public Health, School of Medicine, University of California, San Diego, CA, USA.

[7 ] Denver Health and Hospital Authority, Denver, CO, USA.

Article

Publisher Item ID: S1473-3099(21)00145-6 Mid ID: NIHMS1754436

DOI: 10.1016/S1473-3099(21)00145-6

PMC ID: 8712384

PubMed ID: 34499863

SO-VID: 1b85bc35-909d-42cc-ab47-f94a5a68d270

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