Tomomi Minato: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: ResourcesRole: VisualizationRole: Writing – original draft
Tetsuya Maeda: Role: Data curationRole: Formal analysisRole: InvestigationRole: SupervisionRole:
Writing – review & editing
Yoshiro Fujisawa: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – original draft
Hirokazu Tsuji: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Writing – review & editing
Koji Nomoto: Role: Data curationRole: Formal analysisRole: InvestigationRole: MethodologyRole:
Project administrationRole: SupervisionRole: Writing – review & editing
Kinji Ohno: Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: InvestigationRole:
SupervisionRole: ValidationRole: Writing – review & editing
Masaaki Hirayama:
ORCID: http://orcid.org/0000-0003-0092-7837
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: ResourcesRole: SoftwareRole:
SupervisionRole: Writing – original draftRole: Writing – review & editing
Masato Asanuma: Role: Editor
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
1
November
2017
Publication date Collection: 2017
Volume: 12
Issue: 11
Electronic Location Identifier: e0187307
Affiliations
[1
]
Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School
of Medicine, Nagoya, Japan
[2
]
Division of Neurology and Gerontology, Department of Internal Medicine, School of
medicine, Iwate Medical University, Morioka, Japan
[3
]
Yakult Central Institute, Tokyo, Japan
[4
]
Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University
Graduate School of Medicine, Nagoya, Japan
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
JAPAN
Author notes
Competing Interests: HT and KN are employees of the Yakult Central Institute. This does not alter our adherence
to PLOS ONE policies on sharing data and materials. The other authors have no competing
interests to declare.
Author information
Article
Publisher ID:
PONE-D-17-23989
DOI: 10.1371/journal.pone.0187307
PMC ID: 5665539
PubMed ID: 29091972
SO-VID: 1d42e880-68f0-4577-ab4f-41161c2f1567
Copyright © © 2017 Minato et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: Japan Society for the Promotion of Science (JP)
Award ID: 24500458
Award Recipient
:
ORCID: http://orcid.org/0000-0003-0092-7837
Masaaki Hirayama
Funded by: Japan Society for the Promotion of Science (JP)
Award ID: 15H04840
Award Recipient
:
Kinji Ohno
Funded by: Japan Agency for Medical Research and Development (JP)
Award ID: 17gm1010002h0002
Award Recipient
:
Kinji Ohno
Funded by: Smoking Research Foundation (JP)
Award Recipient
:
Kinji Ohno
The authors acknowledge funding by the Japan Society for the Promotion of Science
(JP) (24500458, 15H04840) (
http://www.jsps.go.jp/), the Japan Agency for Medical Research and Development (JP) (17gm1010002h0002) (
http://www.amed.go.jp/); and Smoking Research Foundation (JP) (
http://www.srf.or.jp/). The Yakult Central Institute provided support in the form of salaries for HT and
KN, but did not play any further role in study design, data collection and analysis,
decision to publish, or preparation of the manuscript. HT and KN blindly quantified
intestinal microbiota, and were not involved in the data analysis. HT and KN provided
essential experimental information, but did not affect the results and interpretation
of our study.
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Neurology
Subject:
Neurodegenerative Diseases
Subject:
Movement Disorders
Subject:
Parkinson Disease
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Gut Bacteria
Subject:
Bifidobacterium
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Gastrointestinal Tract
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Digestive System
Subject:
Gastrointestinal Tract
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Gut Bacteria
Subject:
Lactobacillus
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
Subject:
Gut Bacteria
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System
Subject:
Innate Immune System
Subject:
Cytokines
Subject:
Biology and Life Sciences
Subject:
Developmental Biology
Subject:
Molecular Development
Subject:
Cytokines
Subject:
Medicine and Health Sciences
Subject:
Gastroenterology and Hepatology
Subject:
Constipation
Subject:
Medicine and Health Sciences
Subject:
Diagnostic Medicine
Subject:
Signs and Symptoms
Subject:
Constipation
Subject:
Medicine and Health Sciences
Subject:
Pathology and Laboratory Medicine
Subject:
Signs and Symptoms
Subject:
Constipation
Subject:
Biology and Life Sciences
Subject:
Organisms
Subject:
Bacteria
