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      Supercomplex assembly determines electron flux in the mitochondrial electron transport chain.

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          Abstract

          The textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This model (known as the fluid model) is challenged by the proposal that all RCs except complex II can associate in supercomplexes (SCs). The proposed SCs are the respirasome (complexes I, III, and IV), complexes I and III, and complexes III and IV. The role of SCs is unclear, and their existence is debated. By genetic modulation of interactions between complexes I and III and III and IV, we show that these associations define dedicated CoQ and cyt c pools and that SC assembly is dynamic and organizes electron flux to optimize the use of available substrates.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          1095-9203
          0036-8075
          Jun 28 2013
          : 340
          : 6140
          Affiliations
          [1 ] Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid, Spain.
          Article
          340/6140/1567
          10.1126/science.1230381
          23812712
          1d79bfb2-1889-41ea-9c5b-6f630d54f540
          History

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