Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

Author(s): Hong-Wen Liu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Lanlan Chen ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Chengyan Xu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Zhe Li ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Haiyang Zhang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Xiao-Bing Zhang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Weihong Tan ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵

Publication date (Electronic): 2018

Journal: Chemical Society Reviews

Publisher: Royal Society of Chemistry (RSC)

Read this article at

ScienceOpenPublisher PubMed

Bookmark

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

An overview of recent advances in small-molecule enzymatic fluorescent probes for cancer imaging, including design strategies and cancer imaging applications.

Abstract

Abnormal enzymatic activities are directly related to the development of cancers. Identifying the location and expression levels of these enzymes in live cancer cells have considerable importance in early-stage cancer diagnoses and monitoring the efficacy of therapies. Small-molecule fluorescent probes have become a powerful tool for the detection and imaging of enzymatic activities in biological systems by virtue of their higher sensitivity, nondestructive fast analysis, and real-time detection abilities. Moreover, due to their structural tailorability, numerous small-molecule enzymatic fluorescent probes have been developed to meet various demands involving real-time tracking and visualizing different enzymes in live cancer cells or in vivo. In this review, we provide an overview of recent advances in small-molecule enzymatic fluorescent probes mainly during the past decade, including the design strategies and applications for various enzymes in live cancer cells. We also highlight the challenges and opportunities in this rapidly developing field of small-molecule fluorescent probes for interventional surgical imaging, as well as cancer diagnosis and therapy.

Related collections

Most cited references 313

Record: found
Abstract: found
Article: not found

Ras oncogenes: split personalities.

Antoine E. Karnoub, Robert Weinberg (2008)

Extensive research on the Ras proteins and their functions in cell physiology over the past 30 years has led to numerous insights that have revealed the involvement of Ras not only in tumorigenesis but also in many developmental disorders. Despite great strides in our understanding of the molecular and cellular mechanisms of action of the Ras proteins, the expanding roster of their downstream effectors and the complexity of the signalling cascades that they regulate indicate that much remains to be learnt.

0 comments Cited 431 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

New strategies for fluorescent probe design in medical diagnostic imaging.

Hisataka Kobayashi, Mikako Ogawa, Raphael Alford … (2010)

0 comments Cited 394 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Fluorescent chemosensors: the past, present and future.

Di Wu, Adam Sedgwick, Thorfinnur Gunnlaugsson … (2017)

Fluorescent chemosensors for ions and neutral analytes have been widely applied in many diverse fields such as biology, physiology, pharmacology, and environmental sciences. The field of fluorescent chemosensors has been in existence for about 150 years. In this time, a large range of fluorescent chemosensors have been established for the detection of biologically and/or environmentally important species. Despite the progress made in this field, several problems and challenges still exist. This tutorial review introduces the history and provides a general overview of the development in the research of fluorescent sensors, often referred to as chemosensors. This will be achieved by highlighting some pioneering and representative works from about 40 groups in the world that have made substantial contributions to this field. The basic principles involved in the design of chemosensors for specific analytes, problems and challenges in the field as well as possible future research directions are covered. The application of chemosensors in various established and emerging biotechnologies, is very bright.