For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
31
views
129
references
 Top references
cited by
40
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    2
    shares
      1,035
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      The Dark Side of Cell Fusion

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Cell fusion is a physiological cellular process essential for fertilization, viral entry, muscle differentiation and placental development, among others. In this review, we will highlight the different cancer cell-cell fusions and the advantages obtained by these fusions. We will specially focus on the acquisition of metastatic features by cancer cells after fusion with bone marrow-derived cells. The mechanism by which cancer cells fuse with other cells has been poorly studied thus far, but the presence in several cancer cells of syncytin, a trophoblastic fusogen, leads us to a cancer cell fusion mechanism similar to the one used by the trophoblasts. The mechanism by which cancer cells perform the cell fusion could be an interesting target for cancer therapy.

          Related collections

          Most cited references129

          • Record: found
          • Abstract: found
          • Article: not found

          Epithelial-mesenchymal transitions in development and disease.

          Jean Paul Thiery, Hervé Acloque, Ruby Y J Huang … (2009)
          The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.
          Article 0 comments Cited 3685 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Microenvironmental regulation of metastasis.

            Johanna A. Joyce, Jeffrey W Pollard (2009)
            Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate-limiting steps that are influenced by non-malignant cells of the tumour microenvironment. Many of these cells are derived from the bone marrow, particularly the myeloid lineage, and are recruited by cancer cells to enhance their survival, growth, invasion and dissemination. This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues.
            Article 0 comments Cited 1179 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              The distribution of secondary growths in cancer of the breast. 1889.

              S. PAGET (1989)
              Article 0 comments Cited 579 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Lajos Kemény: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Int J Mol Sci
                Journal ID (iso-abbrev): Int J Mol Sci
                Journal ID (publisher-id): ijms
                Title: International Journal of Molecular Sciences
                Publisher: MDPI
                ISSN (Electronic): 1422-0067
                Publication date (Electronic): 28 April 2016
                Publication date Collection: May 2016
                Volume: 17
                Issue: 5
                Electronic Location Identifier: 638
                Affiliations
                Department of Gynecology Obstetrics, Faculty of Medicine, University of Geneva, ‎Geneva 1211, Switzerland; daniel.bastida@ 123456etu.unige.ch (D.B.-R.); kylie.vanhoesen@ 123456gmail.com (K.V.H.)
                Author notes
                [* ]Correspondence: marie.cohen@ 123456hcuge.ch ; Tel.: +41-22-37-24-381
                [†]

                These authors contributed equally to this work.

                Article
                Publisher ID: ijms-17-00638
                DOI: 10.3390/ijms17050638
                PMC ID: 4881464
                PubMed ID: 27136533
                SO-VID: 204716ae-184a-4fba-953b-dfad39a32268
                Copyright © © 2016 by the authors; licensee MDPI, Basel, Switzerland.
                License:

                This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 29 March 2016
                Date accepted : 22 April 2016
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular biology
                Keywords: cancer,cell fusion,metastasis,drug resistance,syncytin
                Data availability:
                ScienceOpen disciplines: Molecular biology
                Keywords: cancer, cell fusion, metastasis, drug resistance, syncytin

                Comments

                Comment on this article

                scite_

                Similar content1,035

                See all similar

                Cited by38

                See all cited by

                Most referenced authors2,938

                See all reference authors