178
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Microenvironmental regulation of metastasis

      ,
      Nature Reviews Cancer
      Springer Science and Business Media LLC

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Metastasis is a multistage process that requires cancer cells to escape from the primary tumour, survive in the circulation, seed at distant sites and grow. Each of these processes involves rate-limiting steps that are influenced by non-malignant cells of the tumour microenvironment. Many of these cells are derived from the bone marrow, particularly the myeloid lineage, and are recruited by cancer cells to enhance their survival, growth, invasion and dissemination. This Review describes experimental data demonstrating the role of the microenvironment in metastasis, identifies areas for future research and suggests possible new therapeutic avenues.

          Related collections

          Author and article information

          Journal
          Nature Reviews Cancer
          Nat Rev Cancer
          Springer Science and Business Media LLC
          1474-175X
          1474-1768
          April 2009
          March 12 2008
          April 2009
          : 9
          : 4
          : 239-252
          Article
          10.1038/nrc2618
          3251309
          19279573
          ce14f4ab-8a19-4de4-a8d7-96a2891f6b3c
          © 2009

          http://www.springer.com/tdm

          History

          Comments

          Comment on this article