Childhood Leukemia in Small Geographical Areas and Proximity to Industrial Sources of Air Pollutants in Three Colombian Cities

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

Acute leukemia is the most common childhood cancer and has been associated with exposure to environmental carcinogens. This study aimed to identify clusters of acute childhood leukemia (ACL) cases and analyze their relationship with proximity to industrial sources of air pollution in three capital cities in Colombia during 2000–2015. Incident ACL cases were obtained from the population cancer registries for the cities of Bucaramanga, Cali, and Medellín. The inventory of industrial sources of emissions to the air was obtained from the regional environmental authorities and industrial conglomerates were identified. The Kulldorf’s circular scan test was used to detect city clusters and to identify clusters around industrial conglomerates. Multivariable spatial modeling assessed the effect of distance and direction from the industrial conglomerates controlling for socioeconomic status. We identified industrials sectors within a buffer of 1 km around industrial conglomerates related to the ACL clusters. Incidence rates showed geographical heterogeneity with low spatial autocorrelation within cities. The spatio-temporal tests identified one cluster in each city. The industries located within 1 km around the ACL clusters identified in the three cities represent different sectors. Exposure to air pollution from industrial sources might be contributing to the incidence of ACL cases in urban settings in Colombia.

Related collections

Most cited references 50

Record: found
Abstract: found
Article: found

Is Open Access

International incidence of childhood cancer, 2001–10: a population-based registry study

Eva Steliarova-Foucher, Murielle Colombet, Lynn A. G. Ries … (2017)

Summary Background Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer incidence in the past two decades are scarce. This study aimed to provide internationally comparable local data on the incidence of childhood cancer to promote research of causes and implementation of childhood cancer control. Methods This population-based registry study, devised by the International Agency for Research on Cancer in collaboration with the International Association of Cancer Registries, collected data on all malignancies and non-malignant neoplasms of the CNS diagnosed before age 20 years in populations covered by high-quality cancer registries with complete data for 2001–10. Incidence rates per million person-years for the 0–14 years and 0–19 years age groups were age-adjusted using the world standard population to provide age-standardised incidence rates (WSRs), using the age-specific incidence rates (ASR) for individual age groups (0–4 years, 5–9 years, 10–14 years, and 15–19 years). All rates were reported for 19 geographical areas or ethnicities by sex, age group, and cancer type. The regional WSRs for children aged 0–14 years were compared with comparable data obtained in the 1980s. Findings Of 532 invited cancer registries, 153 registries from 62 countries, departments, and territories met quality standards, and contributed data for the entire decade of 2001–10. 385 509 incident cases in children aged 0–19 years occurring in 2·64 billion person-years were included. The overall WSR was 140·6 per million person-years in children aged 0–14 years (based on 284 649 cases), and the most common cancers were leukaemia (WSR 46·4), followed by CNS tumours (WSR 28·2), and lymphomas (WSR 15·2). In children aged 15–19 years (based on 100 860 cases), the ASR was 185·3 per million person-years, the most common being lymphomas (ASR 41·8) and the group of epithelial tumours and melanoma (ASR 39·5). Incidence varied considerably between and within the described regions, and by cancer type, sex, age, and racial and ethnic group. Since the 1980s, the global WSR of registered cancers in children aged 0–14 years has increased from 124·0 (95% CI 123·3–124·7) to 140·6 (140·1–141·1) per million person-years. Interpretation This unique global source of childhood cancer incidence will be used for aetiological research and to inform public health policy, potentially contributing towards attaining several targets of the Sustainable Development Goals. The observed geographical, racial and ethnic, age, sex, and temporal variations require constant monitoring and research. Funding International Agency for Research on Cancer and the Union for International Cancer Control.

0 comments Cited 370 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: found
Article: not found

Paediatric cancer in low-income and middle-income countries.

Ian Magrath, Eva Steliarova-Foucher, Sidnei Epelman … (2013)

Patterns of cancer incidence across the world have undergone substantial changes as a result of industrialisation and economic development. However, the economies of most countries remain at an early or intermediate stage of development-these stages are characterised by poverty, too few health-care providers, weak health systems, and poor access to education, modern technology, and health care because of scattered rural populations. Low-income and middle-income countries also have younger populations and therefore a larger proportion of children with cancer than high-income countries. Most of these children die from the disease. Chronic infections, which remain the most common causes of disease-related death in all except high-income countries, can also be major risk factors for childhood cancer in poorer regions. We discuss childhood cancer in relation to global development and propose strategies that could result in improved survival. Education of the public, more and better-trained health professionals, strengthened cancer services, locally relevant research, regional hospital networks, international collaboration, and health insurance are all essential components of an enhanced model of care. Copyright © 2013 Elsevier Ltd. All rights reserved.

0 comments Cited 126 times – based on 0 reviews      Review now

Bookmark

Record: found
Abstract: not found
Article: not found

Spatial disease clusters: Detection and inference

Martin Kulldorff, Neville Nagarwalla (1995)

0 comments Cited 115 times – based on 0 reviews      Review now

Bookmark

All references

Author and article information

Journal

Journal ID (nlm-ta): Int J Environ Res Public Health

Journal ID (iso-abbrev): Int J Environ Res Public Health

Journal ID (publisher-id): ijerph

Title: International Journal of Environmental Research and Public Health

Publisher: MDPI

ISSN (Print): 1661-7827

ISSN (Electronic): 1660-4601

Publication date (Electronic): 29 October 2020

Publication date (Print): November 2020

Volume: 17

Issue: 21

Electronic Location Identifier: 7925

Affiliations

[1 ]Department of Public Health, Universidad Industrial de Santander, Bucaramanga 680002, Colombia; avalbuena@ 123456cuentadealtocosto.org

[2 ]Public Health Observatory of Santander, Fundación Oftalmológica de Santander, Floridablanca 681003, Colombia; rasief@ 123456gmail.com (F.E.M.-C.); rafael.ortiz@ 123456foscal.com.co (R.G.O.M.)

[3 ]Cuenta de Alto Costo, Fondo Colombiano de Enfermedades de Alto Costo, Bogotá 110111, Colombia

[4 ]Population Based Cancer Registry of the Metropolitan Area of Bucaramanga, Universidad Autónoma de Bucaramanga, Bucaramanga 681003, Colombia; curibep@ 123456unab.edu.co

[5 ]Population Based Cancer Registry of Antioquia, Gobernación de Antioquia, Medellín 050015, Colombia; mary.brome@ 123456antioquia.gov.co

[6 ]Cancer Institute Las Américas, Medellín 050022, Colombia; hgarcia@ 123456une.net.co

[7 ]Population Based Cancer Registry of Cali, Universidad del Valle, Cali 760043, Colombia; luis.bravo@ 123456correounivalle.edu.co

[8 ]Department of Pediatrics, Universidad Industrial de Santander, Bucaramanga 68002, Colombia; jurgnied@ 123456uis.edu.co

[9 ]Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada; osornio@ 123456ualberta.ca

Author notes

[* ]Correspondence: laurovi@ 123456uis.edu.co

Author information

Laura Andrea Rodriguez-Villamizar https://orcid.org/0000-0002-5551-2586

Feisar Enrique Moreno-Corzo https://orcid.org/0000-0002-5007-3422

Ana María Valbuena-Garcia https://orcid.org/0000-0002-3668-311X

Rafael Gustavo Ortiz Martínez https://orcid.org/0000-0002-8401-4834

Alvaro R. Osornio-Vargas https://orcid.org/0000-0001-8287-7102

Article

Publisher ID: ijerph-17-07925

DOI: 10.3390/ijerph17217925

PMC ID: 7662935

PubMed ID: 33137878

SO-VID: 206549df-342c-4cf8-abec-9f870511ddce

License:

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

Childhood Leukemia in Small Geographical Areas and Proximity to Industrial Sources of Air Pollutants in Three Colombian Cities

Read this article at

Abstract

Related collections

Global Health Next Generation Network

Most cited references 50

International incidence of childhood cancer, 2001–10: a population-based registry study

Paediatric cancer in low-income and middle-income countries.

Spatial disease clusters: Detection and inference

Author and article information

Journal

Affiliations

Author notes

Author information

Article

History

Categories

Comments

Comment on this article

Similar content 26

Cited by 5

Most referenced authors 556