Contributors
Haixia Xu: Role: InvestigationRole: Writing – original draft
Xiao Du: Role: InvestigationRole: Resources
Jia Xu: Role: InvestigationRole: Writing – original draft
Yu Zhang: Role: Investigation
Yan Tian: Role: Funding acquisitionRole: InvestigationRole: Project administration
Geng Liu: Role: Investigation
Xiuxuan Wang: Role: Formal analysisRole: Investigation
Meilin Ma: Role: Investigation
Wenya Du:
ORCID: http://orcid.org/0000-0002-1484-4322
Role: Investigation
Yu Liu: Role: InvestigationRole: Methodology
Lunzhi Dai:
ORCID: http://orcid.org/0000-0002-3003-8910
Role: Formal analysisRole: Supervision
Wendong Huang: Role: ResourcesRole: Supervision
Nanwei Tong: Role: Formal analysisRole: Resources
Yuquan Wei: Role: ResourcesRole: Supervision
Xianghui Fu:
ORCID: http://orcid.org/0000-0001-9808-3892
Role: ConceptualizationRole: Funding acquisitionRole: Project administrationRole:
SupervisionRole: Writing – original draftRole: Writing – review & editing
Chengran Xu: Role: Academic Editor
Journal
Journal ID (nlm-ta): PLoS Biol
Journal ID (iso-abbrev): PLoS Biol
Journal ID (publisher-id): plos
Journal ID (pmc): plosbiol
Title:
PLoS Biology
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1544-9173
ISSN
(Electronic):
1545-7885
Publication date
(Electronic):
24
February
2020
Publication date Collection:
February
2020
Publication date PMC-release: 24
February
2020
Volume: 18
Issue: 2
Electronic Location Identifier: e3000603
Affiliations
[1
]
Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics,
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan
University and Collaborative Innovation Center of Biotherapy, Chengdu, China
[2
]
Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu,
China
[3
]
Department of General Surgery, Yaan People's Hospital, Yaan, Sichuan, China
[4
]
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan
University and Collaborative Innovation Center of Biotherapy, Chengdu, China
[5
]
Department of General Practice and Lab of PTM, State Key Laboratory of Biotherapy,
West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy,
Chengdu, China
[6
]
Department of Diabetes Complications and Metabolism, Beckman Research Institute of
City of Hope, Duarte, California, United States of America
[7
]
Division of Endocrinology and Metabolism, West China Hospital, Sichuan University,
Chengdu, China
Author notes
The authors have declared that no competing interests exist.
Author information
Article
Publisher ID:
PBIOLOGY-D-18-01531
DOI: 10.1371/journal.pbio.3000603
PMC ID: 7058362
PubMed ID: 32092075
SO-VID: 2188378a-7198-4642-a903-e8c67bba756f
Copyright © © 2020 Xu et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 17
December
2018
Date
accepted
: 31
January
2020
Page count
Figures: 8,
Tables: 0,
Pages: 36
Funding
Funded by: funder-id http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
Award ID: 91540113
Award Recipient
:
ORCID: http://orcid.org/0000-0001-9808-3892
Xianghui Fu
Funded by: funder-id http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
Award ID: 81570527
Award Recipient
:
ORCID: http://orcid.org/0000-0001-9808-3892
Xianghui Fu
Funded by: funder-id http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
Award ID: 81502631
Award Recipient
:
Yan Tian
Funded by: funder-id http://dx.doi.org/10.13039/501100002855, Ministry of Science and Technology of the People's Republic of China;
Award ID: 2018ZX09201018-005
Award Recipient
:
ORCID: http://orcid.org/0000-0001-9808-3892
Xianghui Fu
Funded by: National Natural Science Foundation of China
Award ID: 81970561
Award Recipient
:
ORCID: http://orcid.org/0000-0001-9808-3892
Xianghui Fu
Funded by: the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University
Award ID: ZYJC18049
Award Recipient
:
ORCID: http://orcid.org/0000-0001-9808-3892
Xianghui Fu
Funded by: National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University
Award ID: Z20191005
Award Recipient
:
ORCID: http://orcid.org/0000-0001-9808-3892
Xianghui Fu
This work was supported by the Ministry of Science and Technology of China (2018ZX09201018-005
to XF), the National Natural Science Foundation of China (91540113, 81970561, and
81570527 to XF, and 81502631 to YT), the 1.3.5 Project for Disciplines of Excellence,
West China Hospital, Sichuan University (ZYJC18049 to XF), and National Clinical Research
Center for Geriatrics, West China Hospital, Sichuan University (Z20191005 to XF).
Categories
Subject:
Research Article
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Diabetic Endocrinology
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Hormones
Subject:
Insulin
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Structures and Organelles
Subject:
Vesicles
Subject:
Exosomes
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Obesity
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Endocrine Physiology
Subject:
Insulin Resistance
Subject:
Medicine and Health Sciences
Subject:
Endocrinology
Subject:
Endocrine Physiology
Subject:
Insulin Secretion
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Endocrine Physiology
Subject:
Insulin Secretion
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Endocrine Physiology
Subject:
Insulin Secretion
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Nucleic acids
Subject:
RNA
Subject:
Non-coding RNA
Subject:
Natural antisense transcripts
Subject:
MicroRNAs
Subject:
Biology and life sciences
Subject:
Genetics
Subject:
Gene expression
Subject:
Gene regulation
Subject:
MicroRNAs
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Homeostasis
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Processes
Subject:
Homeostasis
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