Temporal and spatial distribution trends of polio vaccine coverage in less than one-year old children in Brazil, 2011–2021

Background

Low polio vaccine coverage can result in the spread of Poliovirus to areas free from viral circulation. This study analyzed the temporal trends and spatial distribution of polio vaccine coverage in one year-old children in Brazil, between 2011 and 2021. Methods: This was an ecological, time-series study (2011 to 2021) with annual vaccine coverages against poliomyelitis, extracted from the Information System of the National Immunization Program from the 26 States and the Distrito Federal (DF). The percentage reductions in vaccination coverage in Brazil and in the Regions were calculated. Prais-Winsten regression models were used to analyze time series for the Regions and States, and spatial analysis identified the distribution of clusters (high-high; low-low; high-low and low-high) of vaccination coverages across Brazilian municipalities, using a 5% significance level. Results: From 2011 to 2021, the coverage of polio vaccines decreased by 29,9%. There was a progressive increase observed in clusters resulting in low vaccination coverages (140 low-low Brazilian municipalities in 2011 vs. 403 in 2021), mostly reported in the North and Northeast regions of the country. There was a downward trend in vaccination coverages in 24 of the 26 States and DF (p ≤ 0.05). Conclusions: The reduction in polio vaccine coverage, as observed in the North and Northeast regions of Brazil, may favor the spread of Poliovirus. Therefore, vaccination strategies should be prioritized for children residing in areas with sharp and recurrent declines in vaccination coverages, including travelers, migrants, and refugees.

Supplementary Information

The online version contains supplementary material available at 10.1186/s12889-023-16192-8.

Highlights

Clusters with low coverage of the poliovirus vaccine were concentrated in the North and Northeast regions of Brazil;

Poliomyelitis vaccination strategies in Brazil should be directed, in particular, to areas that present a marked and continuous decrease in vaccine coverage;

Travelers, migrants and refugees should also be included in polio vaccination strategies in Brazil.

Supplementary Information

The online version contains supplementary material available at 10.1186/s12889-023-16192-8.