High-risk HPV and genital Chlamydia trachomatis infections among outpatients at a central clinic in Shenzhen

Abstract

Objective The objective of this study is to detect the infection rates of high-risk human papillomavirus (HR- HPV) and genital Chlamydia trachomatis (GCT) among outpatients at a cervical clinic in Shenzhen, as well as to explore the associations between these infections and cervical cancer or precancer lesions.

Methods Medical records of the outpatients at cervical clinic in Shenzhen Maternity and Child Healthcare Hospital throughout 2018 were retrospectively collected, and the association between HR-HPV and GCT and cervical lesions was analyzed using non-conditional Logistic regression to calculate odds ratio ( OR) and 95% confidence interval ( CI).

Results In total, 881 cases were included in analysis with a mean age of (36.86±9.46) years. The infection rates of HR-HPV, GCT, and co-infection of GCT and HR-HPV was 71.7%, 7.4%, and 5.6%, respectively. HR-HPV infection increased with age ( P for trend=0.001), while GCT infection and GCT co-infection with HR-HPV decreased with age ( Ptrend=0.002 and 0.014). Multivariate Logistic regression analyses showed that HR-HPV was positively associated with cervical lesions, including both cytology with ASCUS+ and histopathology CIN1+, and the ORs and 95% CIs were 3.72 (2.35, 5.90) and 6.90 (3.79, 12.57). However, we did not observe positive associations of GCT or co- infection of GCT and HR-HPV with cervical lesions.

Conclusion Outpatients at cervical clinics are the key population at risk of HR-HPV and GCT infections in Shenzhen area. Targeted interventions, such as health education, condom use promotion, and routine screening, should be placed on these women.

Abstract

摘要： 目的 分析深圳地区宫颈门诊就诊者高危型人乳头瘤病毒(high-risk human papillomavirus, HR-HPV)和生 殖道沙眼衣原体(genital chlamydia trachomatis, GCT)感染情况及其与子宫颈癌/癌前病变的关联。 方法 回顾性地收集 2018 年 1—12 月深圳市妇幼保健院妇科宫颈门诊就诊者病历资料，采用非条件 Logistic 回归分析高危型 HPV 和 GCT 与 子宫颈病变的关联，计算比值比(odds ratio, OR)和 95% 置信区间(confidence interval, CI)。 结果 本研究纳入深圳市宫 颈门诊就诊者 881 例，平均年龄(36.86±9.46)岁。高危型 HPV 阳性率为 71.7%，GCT 的阳性率为 7.4%，高危型 HPV 合并 GCT 的感染率为 5.6%。高危型 HPV 阳性率随年龄递增( P 趋势=0.001)，而 GCT 阳性率和高危型 HPV 合并 GCT 感染率呈 现随年龄逐渐下降的趋势(趋势性 P=0.002 和 0.014)。多因素 Logistic 回归分析显示，高危型 HPV 感染与细胞学 AS⁃ CUS+及病理学 CIN1+存在显著关联， OR 值及 95% CI 分别为 3.72(2.35, 5.90)和 6.90(3.79, 12.57)；未发现 GCT 感染或高 危型 HPV 合并 GCT 感染与细胞学 ASCUS+及病理学 CIN1+存在关联。 结论 宫颈门诊就诊者是深圳市高危型 HPV 和 GCT 感染的重点人群，需有针对性地做好健康教育、安全套促进和常规筛查工作