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      Rapid detection of human heart-type fatty acid-binding protein in human plasma and blood using a colloidal gold-based lateral flow immunoassay

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          Abstract

          The incidence of acute myocardial infarction (AMI) is currently increasing. Early detection is important for the treatment and prognosis of patients with AMI. Heart-type fatty acid-binding protein (H-FABP) may be used as an early marker of AMI due to its high sensitivity, specificity and prognostic value. Therefore, in the present study, H-FABP was used as a biomarker in a double-antibody sandwich method and colloidal gold-based lateral flow immunoassay to develop a rapid detection kit for H-FABP with a processing time of only 5 min. The sensitivity of the kit in plasma and whole blood was 1 ng/ml and this method had good specificity, exhibiting no cross-reaction with cardiac troponin I, myoglobin or creatine kinase-Mb. The kits had good shelf life and stability, as they were able to be stored at 40˚C for 30 days. A total of 12 clinical samples were collected for detection and the coincidence rate with the ELISA method was up to 91.67%. Therefore, the present study provided a simple, rapid and economical early-detection in-home testing kit.

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          Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015

          Gregory A Roth, Catherine Johnson, Amanuel Abajobir … (2018)
          Background The burden of cardiovascular diseases (CVDs) remains unclear in many regions of the world. Objectives The GBD (Global Burden of Disease) 2015 study integrated data on disease incidence, prevalence, and mortality to produce consistent, up-to-date estimates for cardiovascular burden. Methods CVD mortality was estimated from vital registration and verbal autopsy data. CVD prevalence was estimated using modeling software and data from health surveys, prospective cohorts, health system administrative data, and registries. Years lived with disability (YLD) were estimated by multiplying prevalence by disability weights. Years of life lost (YLL) were estimated by multiplying age-specific CVD deaths by a reference life expectancy. A sociodemographic index (SDI) was created for each location based on income per capita, educational attainment, and fertility. Results In 2015, there were an estimated 422.7 million cases of CVD (95% uncertainty interval: 415.53 to 427.87 million cases) and 17.92 million CVD deaths (95% uncertainty interval: 17.59 to 18.28 million CVD deaths). Declines in the age-standardized CVD death rate occurred between 1990 and 2015 in all high-income and some middle-income countries. Ischemic heart disease was the leading cause of CVD health lost globally, as well as in each world region, followed by stroke. As SDI increased beyond 0.25, the highest CVD mortality shifted from women to men. CVD mortality decreased sharply for both sexes in countries with an SDI >0.75. Conclusions CVDs remain a major cause of health loss for all regions of the world. Sociodemographic change over the past 25 years has been associated with dramatic declines in CVD in regions with very high SDI, but only a gradual decrease or no change in most regions. Future updates of the GBD study can be used to guide policymakers who are focused on reducing the overall burden of noncommunicable disease and achieving specific global health targets for CVD.
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            Epidemiology of cardiovascular disease in China: current features and implications

            Dong Zhao, Jing Liu, Miao Wang … (2018)
            Cardiovascular disease (CVD) is the leading cause of death in China. To develop effective and timely strategies to cope with the challenges of CVD epidemics, we need to understand the current epidemiological features of the major types of CVD and the implications of these features for the prevention and treatment of CVD. In this Review, we summarize eight important features of the epidemiology of CVD in China. Some features indicate a transition in CVD epidemiology owing to interrelated changes in demography, environment, lifestyle, and health care, including the rising burden from atherosclerotic CVD (ischaemic heart disease and ischaemic stroke), declining mortality from haemorrhage stroke, varied regional epidemiological trends in the subtypes of CVD, increasing numbers of patients with moderate types of ischaemic heart disease and ischaemic stroke, and increasing ageing of patients with CVD. Other features highlight the problems that need particular attention, including the high proportion of out-of-hospital death of patients with ischaemic heart disease with insufficient prehospital care; the wide gaps between guideline-recommended goals and levels of lifestyle indicators; and the huge number of patients with undiagnosed, untreated, or uncontrolled hypertension, hypercholesterolaemia, or diabetes mellitus.
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              Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions

              G. FRENS (1973)
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                Author and article information

                Journal
                Journal ID (nlm-ta): Exp Ther Med
                Journal ID (iso-abbrev): Exp Ther Med
                Journal ID (publisher-id): ETM
                Title: Experimental and Therapeutic Medicine
                Publisher: D.A. Spandidos
                ISSN (Print): 1792-0981
                ISSN (Electronic): 1792-1015
                Publication date (Print): November 2021
                Publication date (Electronic): 31 August 2021
                Publication date PMC-release: 31 August 2021
                Volume: 22
                Issue: 5
                Electronic Location Identifier: 1238
                Affiliations
                [1 ]Department of Breast and Thyroid Surgery, Huaihe Hospital of Henan University, Kaifeng, Henan 475004, P.R. China
                [2 ]Cardiovascular Surgery, Huaihe Hospital of Henan University, Kaifeng, Henan 475004, P.R. China
                [3 ]Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, P.R. China
                [4 ]School of Medical Laboratory, Sanquan College of Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China
                Author notes
                Correspondence to: Dr Zhi-Zeng Wang, Joint National Laboratory for Antibody Drug Engineering, Key Laboratory of Cellular and Molecular Immunology of Henan Province, School of Basic Medical Sciences, Henan University, North Section of Jinming Road, Kaifeng, Henan 475004, P.R. China wzhzeng@ 123456126.com

                *Contributed equally

                Article
                Publisher ID: ETM-0-0-10673
                DOI: 10.3892/etm.2021.10673
                PMC ID: 8438696
                PubMed ID: 34539834
                SO-VID: 2626062c-89ec-4b78-a6d3-805c51af820c
                Copyright © Copyright: © Ren et al.
                License:

                This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

                History
                Date received : 11 June 2020
                Date accepted : 15 February 2021
                Funding
                Funding: This work was supported by the Science and Technology Research Project of Kaifeng Science and Technology Bureau (grant no. 1903097), the Science and Technology Department of Henan Province (grant no. 182102310154) and the Key Scientific Research Project Plan of Colleges and Universities in Henan province (grant no. 19B320003).
                Categories
                Subject: Articles

                ScienceOpen disciplines: Medicine
                Keywords: acute myocardial infarction,heart-type fatty acid-binding protein,colloidal gold,rapid detection,plasma,blood
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: acute myocardial infarction, heart-type fatty acid-binding protein, colloidal gold, rapid detection, plasma, blood

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