Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy

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Abstract

Steroidal mineralocorticoid receptor antagonists, when added to a renin-angiotensin system blocker, further reduce proteinuria in patients with chronic kidney disease but may be underused because of a high risk of adverse events.

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Author and article information

Journal

Title: JAMA

Abbreviated Title: JAMA

Publisher: American Medical Association (AMA)

ISSN (Print): 0098-7484

Publication date Created: September 01 2015

Publication date (Print): September 01 2015

Volume: 314

Issue: 9

Page: 884

Affiliations

[1 ]University of Chicago Medicine, Chicago, Illinois

[2 ]Richard L. Roudebush VA Medical Center and Indiana University, Indianapolis

[3 ]Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China

[4 ]Baker IDI Heart and Diabetes Institute, Melbourne, Australia

[5 ]Department of Nephrology, University Medical Center Groeningen, Groeningen, the Netherlands

[6 ]Departments of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany

[7 ]Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases “Aldo e Cele Daccò,” Ranica (Bergamo), Italy8Unit of Nephrology and Dialysis, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy

[8 ]Steno Diabetes Center, Gentofte, Denmark10University of Copenhagen, Copenhagen, Denmark11Aarhus University, Aarhus, Denmark

[9 ]Department of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany

[10 ]Global Clinical Development, Bayer HealthCare AG, Wuppertal, Germany

[11 ]Heart Diseases Research, Global Drug Discovery, Bayer HealthCare AG, Wuppertal, Germany

[12 ]Global Clinical Development, Bayer PLC, Newbury, England

[13 ]MARCO GmbH & Co KG, Düsseldorf, Germany

[14 ]Global Research and Development Statistics, Bayer HealthCare AG, Leverkusen, Germany

[15 ]Institute of Investigation and Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain

Article

DOI: 10.1001/jama.2015.10081

PubMed ID: 26325557

SO-VID: 27a8c980-59ca-4c7e-a003-784b80320a84

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Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy : A Randomized Clinical Trial

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