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      Beyond causes of death: The social determinants of mortality among children aged 1-59 months in Nigeria from 2009 to 2013

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          Abstract

          Background

          Millions of children worldwide suffer and die from conditions for which effective interventions exist. While there is ample evidence regarding these diseases, there is a dearth of information on the social factors associated with child mortality.

          Methods

          The 2014 Verbal and Social Autopsy Study was conducted based on a nationally representative sample of 3,254 deaths that occurred in children under the age of five and were reported on the birth history component of the 2013 Nigerian Demographic and Health Survey. We conducted a descriptive analysis of the preventive and curative care sought and obtained for the 2,057 children aged 1–59 months who died in Nigeria and performed regional (North vs. South) comparisons.

          Results

          A total of 1,616 children died in the northern region, while 441 children died in the South. The majority (72.5%) of deceased children in the northern region were born to mothers who had no education, married at a young age, and lived in the poorest two quintiles of households. When caregivers first noticed that their child was ill, a median of 2 days passed before they sought or attempted to seek healthcare for their children. The proportion of children who reached and departed from their first formal healthcare provider alive was greater in the North (30.6%) than in the South (17.9%) (p<0.001). A total of 548 children were moderately or severely sick at discharge from the first healthcare provider, yet only 3.9%-18.1% were referred to a second healthcare provider. Cost, lack of transportation, and distance from healthcare facilities were the most commonly reported barriers to formal care-seeking behavior.

          Conclusions

          Maternal, household, and healthcare system factors contributed to child mortality in Nigeria. Information regarding modifiable social factors may be useful in planning intervention programs to promote child survival in Nigeria and other low-income countries in sub-Saharan Africa.

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          Most cited references38

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          The Recognition of and Care Seeking Behaviour for Childhood Illness in Developing Countries: A Systematic Review

          Background Pneumonia, diarrhoea, and malaria are among the leading causes of death in children. These deaths are largely preventable if appropriate care is sought early. This review aimed to determine the percentage of caregivers in low- and middle-income countries (LMICs) with a child less than 5 years who were able to recognise illness in their child and subsequently sought care from different types of healthcare providers. Methods and Findings We conducted a systematic literature review of studies that reported recognition of, and/or care seeking for episodes of diarrhoea, pneumonia or malaria in LMICs. The review is registered with PROSPERO (registration number: CRD42011001654). Ninety-one studies met the inclusion criteria. Eighteen studies reported data on caregiver recognition of disease and seventy-seven studies on care seeking. The median sensitivity of recognition of diarrhoea, malaria and pneumonia was low (36.0%, 37.4%, and 45.8%, respectively). A median of 73.0% of caregivers sought care outside the home. Care seeking from community health workers (median: 5.4% for diarrhoea, 4.2% for pneumonia, and 1.3% for malaria) and the use of oral rehydration therapy (median: 34%) was low. Conclusions Given the importance of this topic to child survival programmes there are few published studies. Recognition of diarrhoea, malaria and pneumonia by caregivers is generally poor and represents a key factor to address in attempts to improve health care utilisation. In addition, considering that oral rehydration therapy has been widely recommended for over forty years, its use remains disappointingly low. Similarly, the reported levels of care seeking from community health workers in the included studies are low even though global action plans to address these illnesses promote community case management. Giving greater priority to research on care seeking could provide crucial evidence to inform child mortality programmes.
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            The Epidemiologic Transition: Changing Patterns of Mortality and Population Dynamics.

            The epidemiologic transition describes changing patterns of population age distributions, mortality, fertility, life expectancy, and causes of death. A number of critiques of the theory have revealed limitations, including an insufficient account of the role of poverty in determining disease risk and mortality, a failure to distinguish adequately the risk of dying from a given cause or set of causes from the relative contributions of various causes of death to overall mortality, and oversimplification of the transition patterns, which do not fit neatly into either historical periods or geographic locations. Recent developments in epidemiologic methods reveal other limitations. A life course perspective prompts examination of changes in causal pathways across the life span when considering shifts in the age distribution of a population as described by the epidemiologic transition theory. The ecological model assumes multiple levels of determinants acting in complex and interrelated ways, with higher level determinants exhibiting emergent properties. Development, testing, and implementation of innovative approaches to reduce the risks associated with the sedentary lifestyle and hyper nutrition in developed countries should not overshadow the continuing threat from infectious diseases, especially resistant strains or newly encountered agents. Interventions must fit populations and the threats to health they experience, while anticipating changes that will emerge with success in some areas. This will require new ways of thinking that go beyond the epidemiologic transition theory.
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              Active and passive immunity, vaccine types, excipients and licensing.

              Abstract Immunity is the state of protection against infectious disease conferred either through an immune response generated by immunization or previous infection or by other non-immunological factors. This article reviews active and passive immunity and the differences between them: it also describes the four different commercially available vaccine types (live attenuated, killed/inactivated, subunit and toxoid): it also looks at how these different vaccines generate an adaptive immune response.
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                Author and article information

                Contributors
                Role: Editor
                Journal
                PLoS One
                PLoS ONE
                plos
                plosone
                PLoS ONE
                Public Library of Science (San Francisco, CA USA )
                1932-6203
                31 May 2017
                2017
                : 12
                : 5
                : e0177025
                Affiliations
                [1 ]Institute for International Programs/ Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
                [2 ]National Population Commission, Abuja, Nigeria
                [3 ]UNICEF, New York, New York, United States of America
                [4 ]USAID, Abuja, Nigeria
                Centre Hospitalier Universitaire Vaudois, FRANCE
                Author notes

                Competing Interests: The authors have declared that no competing interests exist.

                • Conceptualization: REB HDK.

                • Data curation: AKK.

                • Formal analysis: AKK.

                • Funding acquisition: REB HDK.

                • Investigation: HDK AKK ENL.

                • Methodology: AKK HDK.

                • Project administration: HDK AKK ENL.

                • Resources: HDK AKK.

                • Software: AKK.

                • Supervision: REB HDK.

                • Validation: AKK HDK.

                • Visualization: AKK JQ HDK.

                • Writing – original draft: AKK JQ ENL JM.

                • Writing – review & editing: AKK HDK JQ REB JM.

                Author information
                http://orcid.org/0000-0003-3499-0949
                Article
                PONE-D-17-01164
                10.1371/journal.pone.0177025
                5451019
                28562610
                28ef98bb-53f5-45ac-ad7b-f1239ab21ef7
                © 2017 Koffi et al

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 10 January 2017
                : 26 March 2017
                Page count
                Figures: 7, Tables: 3, Pages: 22
                Funding
                Funded by: funder-id http://dx.doi.org/10.13039/100000200, United States Agency for International Development;
                Award ID: GHS-A-00-09-00004-00
                Award Recipient :
                Funded by: funder-id http://dx.doi.org/10.13039/100000865, Bill and Melinda Gates Foundation;
                Award ID: GHS-A-00-09-00004-00
                Award Recipient :
                Funding for the Verbal and Social Autopsy field work was provided by U.S. Agency for International Development/Nigeria and the Office of Population and Reproductive Health, U.S. Agency for International Development/Washington D.C., through a Leader with Associates (LWA) Cooperative Agreement under the terms of Award No GHS-A-00-09-00004-00 to Johns Hopkins University. Funding for technical assistance for the survey was provided through a grant to Maternal and Child Epidemiology Estimation (MCEE) that is supported by the Bill and Melinda Gates Foundation under Global Development Grant #OPP1096225 to Johns Hopkins University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
                Categories
                Research Article
                Medicine and Health Sciences
                Pediatrics
                Child Health
                Medicine and Health Sciences
                Public and Occupational Health
                Child Health
                Medicine and Health Sciences
                Health Care
                Health Care Providers
                People and Places
                Population Groupings
                Age Groups
                Children
                People and Places
                Population Groupings
                Families
                Children
                People and Places
                Geographical Locations
                Africa
                Nigeria
                People and Places
                Demography
                Death Rates
                Medicine and Health Sciences
                Health Care
                Health Care Facilities
                Medicine and Health Sciences
                Surgical and Invasive Medical Procedures
                Autopsy
                People and Places
                Population Groupings
                Families
                Mothers
                Custom metadata
                Data are from the VASA study and are available at the following DOI: 10.6084/m9.figshare.4990913.

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                Uncategorized

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