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      Saturación de oxígeno, respiración periódica y apnea durante el sueño en lactantes de 1 a 4 meses a 2560 metros de altura Translated title: Oxygen saturation, periodic breathing and apnea during sleep in infants 1 to 4 month old living at 2,560 meters above sea level

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          Abstract

          Los estudios sobre polisomnografía en lactantes entre los 2200 m y los 2800 m de altura son escasos. Esta investigación tuvo como objetivo describir la saturación de oxígeno (SpO2) durante el sueño en niños de 1-4 meses a 2560 m y, como objetivos secundarios, la descripción de los índices de apnea y respiración periódica (RP). Se realizaron polisomnografías en 35 lactantes sanos de 1-4 meses en Cuenca (Ecuador) a 2560 m. La mediana para la SpO2 fue 92% y 4,9% para la RP. El índice de apnea central tuvo una mediana de 23,7/hora, que disminuyó a 4,5/hora al descontar las apneas asociadas a RP. No hubo correlación entre la RP y la SpO2. Conclusión: la SpO2 fue inferior a los valores del nivel del mar, y la RP y el índice de apnea central, mayores. Cuando las apneas asociadas a RP se descontaron, el índice de apnea central fue similar al del nivel del mar.

          Translated abstract

          There are few data in the literature related to polysomnography in infants in altitudes from2,200m to 2,800m. The main objective of this investigation was to describe oxygen saturation (SpO2) levels during sleep in infants aged between 1 and 4 months living at an altitude of 2,560 m. The secondary objectives were the description of periodic breathing (PB) and apnea indexes. Polysomnography was performed in 35 healthy infants 1-4 months in Cuenca (Ecuador) at 2,560 m. The median for SpO2 was 92% and 4.9% for PB. The median for the central apnea index was 23.7/hour and 15.4/hour when related to PB. No correlation was found between PB and SpO2. Conclusion: SpO2 was lower than the values at sea level and PB and central apnea indexwere higher. When apneas associated with PB were not considered, the central apnea indexwas similar to that found at sea level.

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          Overnight Polysomnographic Characteristics and Oxygen Saturation of Healthy Infants, 1 to 18 Months of Age, Born and Residing At High Altitude (2,640 Meters)

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            Arterial oxygen saturation in healthy newborns delivered at term in Cerro de Pasco (4340 m) and Lima (150 m)

            Background High altitude is associated with both low pulse oxygen saturation at birth and more pre-term deliveries. The present study was performed to determine pulse oxygen saturation in newborns at term in Cerro de Pasco (4340 m) and Lima (150 m) to test the hypothesis that low pulse oxygen saturation at birth at high altitudes was not observed at term deliveries. Methods The present study was designed to determine pulse oxygen saturation values through 1 minute to 24 hours and values of Apgar score at 1 and 5 minutes in newborns delivered at term in Cerro de Pasco (4340 m) and Lima (150 m). Pulse oxygen saturation was recorded in 39 newborns from Cerro de Pasco (4340 m) and 131 from Lima (150 m) at 1, 2, 3, 4, 5, 10, 15, 30 minutes and 1, 2, 8 and 24 hours after delivery. Apgar score was assessed at 1 and 5 minutes after birth. Neurological score was assessed at 24 h of birth by Dubowitz exam. Results Pulse oxygen saturation increased significantly from 1 to 15 min after birth at sea level and from 1 to 30 minutes at Cerro de Pasco. Thereafter, it increased slightly such that at 30 min at sea level and at 60 minutes in Cerro de Pasco it reached a plateau up to 24 hours after birth. At all times, pulse oxygen saturation was significantly higher at sea level than at high altitude (P < 0.01). At 1 minute of life, pulse oxygen saturation was 15% lower at high altitude than at sea level. Apgar score at 1 minute was significantly lower at high altitude (P < 0.05). Neurological score at 24 hours was also lower at high altitude than at sea level. Head circumference, and Apgar score at 5 minutes were similar at sea level and at high altitude (P:NS). Incidence of low birth-weight (<2500 g) at high altitude (5.4%) was similar to that observed at sea level (2.29%) (P:NS). Incidences of low pulse oxygen saturation (<30%), low Apgar score at first minute (<7) and low neurological score at 24 h (<19) were significantly higher at high altitude than at sea level (P < 0.0001; P < 0.0001; and P < 0.001, respectively). Conclusion From these analyses may be concluded that pulse oxygen saturation at 4340 m was significantly low despite the fact that births occurred at term. Apgar scores at first minute and neurological scores were also lower at high altitudes.
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              Apnea and periodic breathing in normal full-term infants during the first twelve months

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                aap
                Archivos argentinos de pediatría
                Arch. argent. pediatr.
                Sociedad Argentina de Pediatría (Buenos Aires, , Argentina )
                0325-0075
                1668-3501
                August 2015
                : 113
                : 4
                : 341-344
                Affiliations
                [03] Bogotá orgnameFundación Clínica Shaio orgdiv1Departamento de Neurología y Laboratorio de Sueño Colombia
                [02] orgnamePontificia Universidad Javeriana orgdiv1Departamentos de Pediatría y Epidemiología Clínica y Bioestadística
                [05] Cañar orgnameHospital Luis Fernando Martínez orgdiv1Departamento de Pediatría Ecuador
                [06] Bogotá orgnameUniversidad de los Andes orgdiv1Hospital de La Misericordia y Fundación Santa Fe de Bogotá orgdiv2Departamento de Pediatría
                [01] Bogotá orgnameFundación Santa Fe de Bogotá orgdiv1Departamento de Pediatría
                [04] Cuenca orgnameUniversidad del Azuay orgdiv1Hospital del Río orgdiv2Departamento de Pediatría Ecuador
                [07] Bogotá orgnamePontificia Universidad Javeriana orgdiv1Departamento de Epidemiología Clínica y Bioestadística Colombia
                Article
                S0325-00752015000400011
                10.5546/aap.2015.341
                26172010
                291a35a5-585d-4986-a936-e76fd4ea5067

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

                History
                : 23 April 2015
                : 14 February 2015
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 15, Pages: 4
                Product

                SciELO Argentina


                Sueño,Lactante,Altitud,Oxígeno,Polisomnografía,Sleep,Infant,Altitude,Oxygen,Polysomnography

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