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      The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition.

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          Abstract

          It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the present study was to investigate the mRNA expression levels of these genes in the human umbilical vein endothelial cells (HUVECs) under hyperglycemic condition.

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          Author and article information

          Journal
          Journal ID (iso-abbrev): Endocr Regul
          Title: Endocrine regulations
          Publisher: Walter de Gruyter GmbH
          ISSN (Electronic): 1336-0329
          ISSN (Print): 1210-0668
          Publication date (Electronic): Jul 01 2018
          Volume: 52
          Issue: 3
          Affiliations
          [1 ] Molecular Medicine Research Center, Hormozgan Health institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
          [2 ] Department of Genetics and Medical Biotechnology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
          [3 ] Larestan University of Medical Sciences, Larestan, Iran.
          [4 ] Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
          [5 ] Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
          Article
          Publisher Item ID: /j/enr.2018.52.issue-3/enr-2018-0014/enr-2018-0014.xml
          DOI: 10.2478/enr-2018-0014
          PubMed ID: 31517606
          SO-VID: 2c149b02-e739-45a5-acc4-686f1d09dc59
          History

          Keywords: Ago-2,DGCR8,Dicer,Drosha,human umbilical vein endothelial cells,hyperglycemia
          Data availability:
          Keywords: Ago-2, DGCR8, Dicer, Drosha, human umbilical vein endothelial cells, hyperglycemia

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