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      The expression of Drosha, DGCR8, Dicer and Ago-2 genes are upregulated in human umbilical vein endothelial cells under hyperglycemic condition.

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          Abstract

          It has been shown that dysregulation of miRNAs expression contributes to the pathogenesis and progression of the diabetes and diabetes-related complications. Drosha, DGCR8, Dicer, and Ago-2 are involved in the miRNA maturation. The aim of the present study was to investigate the mRNA expression levels of these genes in the human umbilical vein endothelial cells (HUVECs) under hyperglycemic condition.

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          Author and article information

          Journal
          Endocr Regul
          Endocrine regulations
          Walter de Gruyter GmbH
          1336-0329
          1210-0668
          Jul 01 2018
          : 52
          : 3
          Affiliations
          [1 ] Molecular Medicine Research Center, Hormozgan Health institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
          [2 ] Department of Genetics and Medical Biotechnology, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
          [3 ] Larestan University of Medical Sciences, Larestan, Iran.
          [4 ] Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
          [5 ] Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
          Article
          /j/enr.2018.52.issue-3/enr-2018-0014/enr-2018-0014.xml
          10.2478/enr-2018-0014
          31517606
          2c149b02-e739-45a5-acc4-686f1d09dc59
          History

          Ago-2,DGCR8,Dicer,Drosha,human umbilical vein endothelial cells,hyperglycemia

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