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      Anterior Segment Characteristics of Eyes with Anterior Chamber Depth Less than 2.8 mm and Axial Length Greater than 25 mm

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          Abstract

          Introduction

          This study aimed to investigate anterior segment parameters of eyes, with anterior chamber depth (ACD) less than 2.8 mm and axial length greater than 25.0 mm.

          Methods

          This cross-sectional study included 180 myopic eyes of 180 consecutive patients with axial length greater than 25.0 mm. Patients were divided into low ACD (ACD < 2.8 mm, n = 56) and normal ACD (ACD ≥ 2.8 mm, n = 124) groups. Anterior segment parameters were measured using Scheimpflug imaging and ultrasound biomicroscopy. A general linear model was used to compare parameters between the two groups, after adjusting for age and spherical equivalent.

          Results

          Compared with the normal ACD group, the low ACD group had lower values for the following parameters: corneal diameter, trabecular–anterior iris surface angle, angle-opening distance at 500 μm, anterior chamber volume, anterior chamber width, anterior vault, iris thickness at 500 μm, ciliary sulcus-to-sulcus diameter, distance between cornea and sulcus, trabecular–ciliary process distance, maximum ciliary body thickness, ciliary process length, relative anterior vault, relative distance between cornea and sulcus, and relative lens position (general linear model, p < 0.05). In contrast, central corneal thickness, iris curvature, lens thickness, lens vault, and iris–ciliary angle were greater in the low ACD group (general linear model, p < 0.05).

          Conclusion

          A smaller anterior segment, as well as a thicker and more anteriorly positioned lens, may correlate with shallow ACD in eyes with long axial length.

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          Most cited references26

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          Lens vault, thickness, and position in Chinese subjects with angle closure.

          To investigate the association of lens parameters-specifically, lens vault (LV), lens thickness (LT), and lens position (LP)-with angle closure. Prospective, comparative study. One hundred two Chinese subjects with angle closure (consisting of primary angle closure, primary angle-closure glaucoma, and previous acute primary angle closure) attending a glaucoma clinic and 176 normal Chinese subjects with open angles and no evidence of glaucoma recruited from an ongoing population-based cross-sectional study. All participants underwent gonioscopy and anterior-segment optical coherence tomography (AS OCT; Carl Zeiss Meditec, Dublin, CA). Customized software was used to measure LV, defined as the perpendicular distance between the anterior pole of the crystalline lens and the horizontal line joining the 2 scleral spurs, on horizontal AS OCT scans. A-scan biometry (US-800; Nidek Co, Ltd, Tokyo, Japan) was used to measures LT and to calculate LP (defined as anterior chamber depth [ACD] +1/2 LT) and relative LP (RLP; defined as LP/axial length [AL]). Lens parameters and angle closure. Significant differences between angle-closure and normal eyes were found for LV (901±265 vs. 316±272 μm; P<0.001), LT (4.20±0.92 vs. 3.90±0.73 mm; P = 0.01), LT-to-AL ratio (0.18±0.04 vs. 0.16±0.03; P<0.001), ACD (2.66±0.37 vs. 2.95±0.37 mm; P<0.001), and AL (22.86±0.93 vs. 23.92±1.37 mm; P<0.001), but no significant differences were found for LP (4.76±0.51 vs. 4.90±0.54 mm; P = 0.34) or RLP (0.21±0.02 vs. 0.20±0.02; P = 0.14). After adjusting for age, gender, ACD, LT, and RLP, increased LV was associated significantly with angle closure (odds ratio [OR], 48.1; 95% confidence interval [CI], 12.8-181.3, comparing lowest to highest quartile), but no association was found for LT (OR, 1.78; 95% CI, 0.76-4.16), LP (OR, 1.94; 95% CI, 0.59-6.31), or RLP (OR, 2.08; 95% CI, 0.66-6.57). There was low correlation between LV and LT (Pearson's correlation coefficient [PCC], 0.17), between LV and RLP (PCC, 0.08), or between LV and LP (PCC, 0.2). Eyes with angle closure have thicker lenses with greater LV compared with normal eyes. The LV, which represents the anterior portion of the lens, is a novel parameter independently associated with angle closure after adjusting for age, gender, ACD, and LT. Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
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            Quantitative iris parameters and association with narrow angles.

            To investigate the relationship between quantitative iris parameters (iris curvature [I-Curv], iris area [I-Area], and iris thickness) and the presence of narrow angles. Cross-sectional, community-based study. We recruited 2047 subjects >50 years old without ophthalmic symptoms from a community clinic in Singapore. All subjects underwent gonioscopy and anterior segment optical coherence tomography (AS-OCT) under dark conditions. An eye was considered to have narrow angles if the posterior pigmented trabecular meshwork was not visible for >/=180 degrees on nonindentation gonioscopy with the eye in the primary position. Customized software was used on horizontal AS-OCT scans to measure I-Curv, I-Area, and iris thickness 750 mum (IT750) and 2000 mum (IT2000) from the scleral spur. The average of both temporal and nasal measured values of the right eye was used for analysis. The association between iris parameters and narrow angles on gonioscopy. Iris parameters from 1465 eyes (71.6%) were available for analysis. Of these, 315 subjects (21.5%) had narrow angles. The mean I-Curv (0.366 vs 0.259 mm; P /=60 years had stronger associations for most iris parameters with narrow angles than men and younger subjects. Quantitative iris parameters (I-Curv, I-Area, and iris thickness) are independently associated with narrow angles, particularly in women and older subjects. These data provide further insights into the pathogenesis of angle closure in Singaporeans. Proprietary or commercial disclosure may be found after the references. Copyright 2010 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
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              Analysis of intraocular positions of posterior implantable collamer lens by full-scale ultrasound biomicroscopy

              Background To analyze the positions of intraocular posterior Implantable Collamer Lens (ICL) and its possible relationship with vault. Methods This cross-sectional study included 72 patients with high myopia (134 eyes) who were followed up after phakic intraocular lens implantation. The postoperative time ranged from 1 week to 7 years. We obtained the images of ICL by using Compact Touch STS UBM and observed the position of ICL in posterior chamber and ciliary sulcus. The horizontal lines vault was measured and recorded. Results There were various positions in the posterior chamber as observed by full-scale ultrasound biomicroscopy and the haptics were inserted at different positions. -Eight seven eyes (64.9%) that obtained ideal vault, 29 eyes (21.6%) had insufficient vaults and 18 eyes (13.4%) had excessive vault. The vault with various positions of haptics was in ideal range (250 μm–750 μm) almost in each group. Three eyes in this study with haptics on the top of ciliary sulcus obtained excessive vault (mean vault, 850.00 ± 70.71 μm) and one eye appeared one side haptics pushing forward the iris. Among five eyes (3.7%) with iridociliary body cysts, three eyes (60%) obtained ideal vault. One eye (0.7%) with ICL decentralization after implantation surgery had an ideal vault, but the patient had serious glare. Conclusions Though ICL in the posterior chamber had different positions and the haptics in most cases were not in the ciliary sulcus, the postoperative vault was almost in the ideal range.
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                Author and article information

                Contributors
                doctzhouxingtao@163.com
                thronebird31@hotmail.com
                Journal
                Ophthalmol Ther
                Ophthalmol Ther
                Ophthalmology and Therapy
                Springer Healthcare (Cheshire )
                2193-8245
                2193-6528
                14 February 2023
                14 February 2023
                April 2023
                : 12
                : 2
                : 1195-1206
                Affiliations
                GRID grid.8547.e, ISNI 0000 0001 0125 2443, Department of Ophthalmology, Eye and ENT Hospital, NHC Key Laboratory of Myopia, , Fudan University, ; Shanghai, People’s Republic of China
                Author information
                http://orcid.org/0000-0001-8698-3316
                Article
                666
                10.1007/s40123-023-00666-4
                10011296
                36786967
                2c9d742a-667a-4b80-81b0-33928b8c1fc1
                © The Author(s) 2023

                Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

                History
                : 9 December 2022
                : 26 January 2023
                Funding
                Funded by: FundRef http://dx.doi.org/10.13039/501100001809, National Natural Science Foundation of China;
                Award ID: 81770955
                Award Recipient :
                Categories
                Original Research
                Custom metadata
                © The Author(s) 2023

                anterior chamber depth,axial length,myopia,primary angle closure,implantable collamer lens

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