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      Truth in Science Publishing: A Personal Perspective

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      PLoS Biology
      Public Library of Science

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          Abstract

          Scientists, public servants, and patient advocates alike increasingly question the validity of published scientific results, endangering the public’s acceptance of science. Here, I argue that emerging flaws in the integrity of the peer review system are largely responsible. Distortions in peer review are driven by economic forces and enabled by a lack of accountability of journals, editors, and authors. One approach to restoring trust in the validity of published results may be to establish basic rules that render peer review more transparent, such as publishing the reviews (a practice already embraced by some journals) and monitoring not only the track records of authors but also of editors and journals.

          Abstract

          In this Perspective, Thomas C. Südhof describes some of the current challenges to the peer review system that have endangered public acceptance of science and discusses possible avenues to addressing these challenges.

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          Reproducibility: Experimental mismatch in neural circuits.

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            Author and article information

            Journal
            PLoS Biol
            PLoS Biol
            plos
            plosbiol
            PLoS Biology
            Public Library of Science (San Francisco, CA USA )
            1544-9173
            1545-7885
            26 August 2016
            August 2016
            26 August 2016
            : 14
            : 8
            : e1002547
            Affiliations
            [001]Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, California, United States of America
            Author notes

            The author has declared that no competing interests exist.

            Article
            PBIOLOGY-D-16-01004
            10.1371/journal.pbio.1002547
            5001634
            27564858
            2e99230a-7c12-4743-af59-a9920419863d
            © 2016 Thomas C. Südhof

            This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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            Page count
            Figures: 0, Tables: 0, Pages: 4
            Funding
            The author received no specific funding for this work.
            Categories
            Perspective
            Research and Analysis Methods
            Research Assessment
            Peer Review
            People and Places
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            Biology and Life Sciences
            Cell Biology
            Cellular Types
            Animal Cells
            Neurons
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            Research and Analysis Methods
            Research Assessment
            Reproducibility
            Social Sciences
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            Experimental Economics
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            Political Science
            Public Policy
            Taxes
            Social Sciences
            Economics
            Health Economics
            Health Insurance
            Medicine and Health Sciences
            Health Care
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            Life sciences
            Life sciences

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