Effects of lidocaine and the inclusion complex with 2-hydroxypropyl-β-cyclodextrin on cell viability and proliferation of oral squamous cell carcinoma.

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Abstract

Squamous cell carcinoma (SCC) is a malignant disease that affects the oral cavity. Lidocaine has shown antiproliferative and cytotoxic activity on several cell types. The rapid dispersion is a limitation issue; however, the complexation in cyclodextrin improved pharmacological features and modified the drug release. This study investigated the effects of lidocaine (lido) complexed with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD-lido) on cell viability and proliferation of human tongue squamous cell carcinoma SCC9 and SCC25.

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Journal

Journal ID (iso-abbrev): J Pharm Pharmacol

Title: The Journal of pharmacy and pharmacology

Publisher: Wiley

ISSN (Electronic): 2042-7158

ISSN (Print): 0022-3573

Publication date (Electronic): Jul 2018

Volume: 70

Issue: 7

Affiliations

[1 ] Department Foundation Sciences, School of Dental Medicine, East Carolina University, Greenville, NC, USA.

[2 ] Department of Physiological Sciences, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.

[3 ] Department of Immunology and Molecular Biology, São Leopoldo Mandic Research Center, Campinas, SP, Brazil.

[4 ] Laboratory of Environmental Nanotechnology, Institute of Science and Technology of Sorocaba, São Paulo State University (UNESP), Sorocaba, SP, Brazil.

Article

DOI: 10.1111/jphp.12917

PubMed ID: 29633269

SO-VID: 2ee49bf0-9af8-496b-813c-f07178016337

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Keywords: 2-hydroxypropyl-β-cyclodextrin,anticancer activity,lidocaine,squamous cell carcinoma

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Keywords: 2-hydroxypropyl-β-cyclodextrin, anticancer activity, lidocaine, squamous cell carcinoma

Effects of lidocaine and the inclusion complex with 2-hydroxypropyl-β-cyclodextrin on cell viability and proliferation of oral squamous cell carcinoma.

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