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      Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family.

      Nature

      Animals, Cattle, Cloning, Molecular, DNA, genetics, Gene Expression Regulation, Membrane Proteins, Multigene Family, Oocytes, physiology, Protein Conformation, Receptors, GABA-A, Receptors, Nicotinic, gamma-Aminobutyric Acid

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          Abstract

          Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.

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          Journal
          3037384
          10.1038/328221a0

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