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      Cell death: critical control points.

      1 ,
      Cell
      Elsevier BV

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          Abstract

          Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          0092-8674
          0092-8674
          Jan 23 2004
          : 116
          : 2
          Affiliations
          [1 ] Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
          Article
          S0092867404000467
          10.1016/s0092-8674(04)00046-7
          14744432
          33512abe-7d5e-4558-8d7d-bd20effee074
          History

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