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      Acute hyperkalemia leading to flaccid paralysis: a review of hyperkalemic manifestations

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          Abstract

          Hyperkalemia can present with a spectrum of clinical manifestations with progressive EKG changes and life-threatening arrhythmias. Although no formal guidelines exist as to when to initiate treatment for hyperkalemia, it is generally recommended in clinically symptomatic patients with or without EKG changes. Timely diagnosis and reversal can relieve symptoms and prevent life-threatening arrhythmias. We review the EKG changes associated with hyperkalemia and management principles along with an example of a case of severe hyperkalemia resulting in arrhythmia and flaccid paralysis.

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          Patiromer in patients with kidney disease and hyperkalemia receiving RAAS inhibitors.

          Hyperkalemia increases the risk of death and limits the use of inhibitors of the renin-angiotensin-aldosterone system (RAAS) in high-risk patients. We assessed the safety and efficacy of patiromer, a nonabsorbed potassium binder, in a multicenter, prospective trial.
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            Sodium zirconium cyclosilicate in hyperkalemia.

            Hyperkalemia (serum potassium level, >5.0 mmol per liter) is associated with increased mortality among patients with heart failure, chronic kidney disease, or diabetes. We investigated whether sodium zirconium cyclosilicate (ZS-9), a novel selective cation exchanger, could lower serum potassium levels in patients with hyperkalemia.
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              Potassium disorders--clinical spectrum and emergency management.

              Potassium disorders are common and may precipitate cardiac arrhythmias or cardiopulmonary arrest. They are an anticipated complication in patients with renal failure, but may also occur in patients with no previous history of renal disease. They have a broad clinical spectrum of presentation and this paper will highlight the life-threatening arrhythmias associated with both hyperkalaemia and hypokalaemia. Although the medical literature to date has provided a foundation for the therapeutic options available, this has not translated into consistent medical practice. Treatment algorithms have undoubtedly been useful in the management of other medical emergencies such as cardiac arrest and acute asthma. Hence, we have applied this strategy to the treatment of hyperkalaemia and hypokalaemia which may prove valuable in clinical practice.
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                Author and article information

                Journal
                J Community Hosp Intern Med Perspect
                J Community Hosp Intern Med Perspect
                JCHIMP
                Journal of Community Hospital Internal Medicine Perspectives
                Co-Action Publishing
                2000-9666
                15 June 2015
                2015
                : 5
                : 3
                : 10.3402/jchimp.v5.27993
                Affiliations
                Department of Internal Medicine, Reading Health System, West Reading, PA, USA
                Author notes
                [* ]Correspondence to: Paras Karmacharya, Reading Health System, 6th Avenue and Spruce Street, West Reading, PA 19612, USA, Email: paraskarmacharya@ 123456gmail.com
                Article
                27993
                10.3402/jchimp.v5.27993
                4475259
                26091666
                335faa0a-d0de-4e62-ab67-2c4974114cba
                © 2015 Paras Karmacharya et al.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 26 March 2015
                : 10 April 2015
                Categories
                Case Report/ECG Images

                hyperkalemia,arrhythmia,paralysis
                hyperkalemia, arrhythmia, paralysis

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