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Abstract
The concept that the highly reactive hydroxyl radical (HO) could be generated from
an interaction between superoxide (O(2)(-)) and hydrogen peroxide (H(2)O(2)) was proposed
(with Joseph Weiss) in Professor Haber's final paper published in 1934. Until it was
recognized that free radicals are produced in biological systems, this finding seemed
to have no relevance to biology. However, following the discovery that O(2)(-) was
a normal cellular metabolite, it was quickly recognized that the Haber-Weiss reaction
(O(2)(-)+H(2)O(2) -->HO+O(2)+HO(-)) might provide a means to generate more toxic radicals.
Although the basic reaction has a second order rate constant of zero in aqueous solution
and thus cannot occur in biological systems, the ability of iron salts to serve as
catalysts was discussed by these authors. Because transition metal ions, particularly
iron, are present at low levels in biological systems, this pathway (commonly referred
to as the iron-catalyzed Haber-Weiss reaction) has been widely postulated to account
for the in vivo generation of the highly reactive HO. Recent data documenting the
importance of redox regulation of various cellular signaling pathways makes it clear
that free radicals are essential for normal cellular function. However, this also
makes it obvious that disruptions of free radical production or defenses at many different
levels can lead to adverse effects on cells. While the generation of HO, which is
by far the most reactive oxygen species, is generally indicative of an overtly toxic
event, it is through studies at this level that we have reached a better understanding
of free radicals as both signaling molecules and toxic species.