CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients

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Abstract

Multiple sclerosis (MS) disease is carried through inflammatory and degenerative stages. Based on clinical feaures, it can be subdivided into three groups: relapsing-remitting MS, secondary progressive MS, and primary progressive MS. Multiple sclerosis has a multifactorial etiology with an interplay of genetic predisposition, environmental factors, and autoimmune inflammatory mechanism in which play a key role CC-chemokines and its receptors. In this paper, we studied the frequency of CCR5 gene Δ32 allele in a cohort of Sicilian RR-MS patients comparing with general Sicilian population. Also, we evaluate the association between this commonly polymorphism and disability development and age of disease onset in the same cohort. Our results show that presence of CCR5Δ32 is significantly associated with expanded disability status scale score (EDSS) but not with age of disease onset.

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Author and article information

Journal

Journal ID (nlm-ta): Mult Scler Int

Journal ID (publisher-id): MSI

Title: Multiple Sclerosis International

Publisher: Hindawi Publishing Corporation

ISSN (Print): 2090-2654

ISSN (Electronic): 2090-2662

Publication date (Print): 2011

Publication date (Electronic): 23 June 2011

Volume: 2011

Electronic Location Identifier: 153282

Affiliations

Department of Biomorphology and Biotechnologies, University of Messina, 98125 Messina, Italy

Author notes

*Concetta Crisafulli: ccrisafulli@ 123456unime.it

Academic Editor: Oscar Fernandez

Article

DOI: 10.1155/2011/153282

PMC ID: 3195283

PubMed ID: 22096627

SO-VID: 35722c0b-7235-4228-a8b1-3da780497aab

License:

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.