For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
17
views
38
references
 Top references
cited by
35
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      142
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Brief History of Syphilis

      review-article

      Read this article at

      ScienceOpenPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Abstract

          Before the discovery of Treponema pallidum as the etiologic agent, the origins of syphilis have been the subject of several debates. Diverse therapeutic agents were employed in an attempt to cure the disease. Examining the milestones in the history of syphilis, the present article reviews the existing theories that tried to explain the origins of the disease, the approach in art, the cultural and the evolution of the treatments from the empiric means to the discovery of penicillin.

          Related collections

          Most cited references38

          • Record: found
          • Abstract: found
          • Article: not found

          Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features.

          Ameeta E Singh, Barbara Romanowski (1999)
          Syphilis is a chronic disease with a waxing and waning course, the manifestations of which have been described for centuries. It occurs worldwide, and the incidence varies significantly with geographic location. Transmission is mainly by sexual contact. The causative organism, Treponema pallidum, was first described in 1905, but because of the inability to culture the organism and the limitations of direct microscopy, serologic testing is the mainstay of laboratory diagnosis. The disease has been arbitrarily divided into several stages. The primary stage is defined by a chancre at the site of inoculation. The secondary stage is characterized by a polymorphic rash, lymphadenopathy, and other systemic manifestations. A variable asymptomatic latent period follows, which for epidemiologic purposes is divided into early ( 1 year) stages. The early stages (primary, secondary, and early latent) are potentially infectious. The tertiary stage is the most destructive and is marked by cardiovascular and neurologic sequelae and gummatous involvement of any organ system. Congenital infection may result in protean early or late manifestations. Unlike many other bacteria causing infectious diseases, the organism remains sensitive to penicillin, and this remains the mainstay of therapy.
          Article 0 comments Cited 98 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The origin and antiquity of syphilis revisited: an appraisal of Old World pre-Columbian evidence for treponemal infection.

            G Armelagos, Sherilee Harper, K Zuckerman … (2010)
            For nearly 500 years, scholars have argued about the origin and antiquity of syphilis. Did Columbus bring the disease from the New World to the Old World? Or did syphilis exist in the Old World before 1493? Here, we evaluate all 54 published reports of pre-Columbian, Old World treponemal disease using a standardized, systematic approach. The certainty of diagnosis and dating of each case is considered, and novel information pertinent to the dating of these cases, including radiocarbon dates, is presented. Among the reports, we did not find a single case of Old World treponemal disease that has both a certain diagnosis and a secure pre-Columbian date. We also demonstrate that many of the reports use nonspecific indicators to diagnose treponemal disease, do not provide adequate information about the methods used to date specimens, and do not include high-quality photographs of the lesions of interest. Thus, despite an increasing number of published reports of pre-Columbian treponemal infection, it appears that solid evidence supporting an Old World origin for the disease remains absent. Copyright © 2011 Wiley Periodicals, Inc.
            Article 0 comments Cited 34 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              The introduction of 'chemotherapy' using arsphenamine - the first magic bullet.

              J. Williams (2009)
              Article 0 comments Cited 32 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Journal
                Journal ID (nlm-ta): J Med Life
                Journal ID (iso-abbrev): J Med Life
                Journal ID (publisher-id): JMedLife
                Title: Journal of Medicine and Life
                Publisher: Carol Davila University Press (Romania )
                ISSN (Print): 1844-122X
                ISSN (Electronic): 1844-3117
                Publication date (Print): 15 March 2014
                Publication date (Electronic): 25 March 2014
                Volume: 7
                Issue: 1
                Pages: 4-10
                Affiliations
                [* ]Dermatology Department, “Carol Davila” University of Medicine and Pharmacy, Bucharest
                [** ]Dermatology Department, ”Victor Babes” Hospital for Infectious and Tropical Diseases, Bucharest
                Author notes
                Correspondence to:Mircea Tampa, MD, PhD, Assistant Lecturer Sos. Mihai Bravu 281, 3rd District, Bucharest, Romania e-mail: tampa_mircea@yahoo.com phone: 0726382600
                Article
                Publisher ID: JMedLife-07-4
                PMC ID: 3956094
                PubMed ID: 24653750
                SO-VID: 3828e4d7-1c23-4ff8-aece-c61cd563ad49
                Copyright © ©Carol Davila University Press
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 14 September 2013
                Date accepted : 14 January 2014
                Categories
                Subject: Review

                ScienceOpen disciplines: Medicine
                Keywords: syphilis,syphilis treatment,history of syphilis
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: syphilis, syphilis treatment, history of syphilis

                Comments

                Comment on this article

                Similar content142

                See all similar

                Cited by35

                See all cited by

                Most referenced authors109

                See all reference authors