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      Validation of a simple model for the morphology of the T wave in unipolar electrograms.

      American Journal of Physiology - Heart and Circulatory Physiology
      Action Potentials, physiology, Electrocardiography, Heart, anatomy & histology, Humans, Medical Informatics, Models, Cardiovascular, Predictive Value of Tests

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          Abstract

          Local unipolar electrograms (UEGs) permit assessment of local activation and repolarization times at multiple sites simultaneously. However, UEG-based indexes of local repolarization are still debated, in particular for positive T waves. Previous experimental and computer modeling studies have not been able to terminate the debate. In this study we validate a simple theoretical model of the UEG and use it to explain how repolarization statistics in the UEG relate to those in the action potential. The model reconstructs the UEG by taking the difference between an inverted local action potential and a position-independent remote signal. In normal tissue, this extremely simple model predicts T-wave morphology with surprising accuracy while explaining in a readily understandable way why the instant of repolarization is always related to the steepest upstroke of the UEG, both in positive and negative T waves, and why positive T waves are related to early repolarizing sites, whereas negative T waves are related to late repolarizing sites.

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          Author and article information

          Journal
          19465555
          10.1152/ajpheart.00064.2009

          Chemistry
          Action Potentials,physiology,Electrocardiography,Heart,anatomy & histology,Humans,Medical Informatics,Models, Cardiovascular,Predictive Value of Tests

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