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      Bayesian Distributed Lag Models

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          Abstract

          Distributed lag models (DLMs) express the cumulative and delayed dependence between pairs of time-indexed response and explanatory variables. In practical application, users of DLMs examine the estimated influence of a series of lagged covariates to assess patterns of dependence. Much recent methodological work has sought to de- velop flexible parameterisations for smoothing the associated lag parameters that avoid overfitting. However, this paper finds that some widely-used DLMs introduce bias in the estimated lag influence, and are sensitive to the maximum lag which is typically chosen in advance of model fitting. Simulations show that bias and misspecification are dramatically reduced by generalising the smoothing model to allow varying penalisation of the lag influence estimates. The resulting model is shown to have substantially fewer effective parameters and lower bias, providing the user with confidence that the estimates are robust to prior model choice.

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          Models for the relationship between ambient temperature and daily mortality.

          Ambient temperature is an important determinant of daily mortality that is of interest both in its own right and as a confounder of other determinants investigated using time-series regressions, in particular, air pollution. The temperature-mortality relationship is often found to be substantially nonlinear and to persist (but change shape) with increasing lag. We review and extend models for such nonlinear multilag forms. Popular models for mortality by temperature at given lag include polynomial and natural cubic spline curves, and the simple but more easily interpreted linear thresholds model, comprising linear relationships for temperatures below and above thresholds and a flat middle section. Most published analyses that have allowed the relationship to persist over multiple lags have done so by assuming that spline or threshold models apply to mean temperature in several lag strata (e.g., lags 0-1, 2-6, and 7-13). However, more flexible models are possible, and a modeling framework using products of basis functions ("cross-basis" functions) suggests a wide range, some used previously and some new. These allow for stepped or smooth changes in the model coefficients as lags increase. Applying a range of models to data from London suggest evidence for relationships up to at least 2 weeks' lag, with smooth models fitting best but lag-stratified threshold models allowing the most direct interpretation. A wide range of multilag nonlinear temperature-mortality relationships can be modeled. More awareness of options should improve investigation of these relationships and help control for confounding by them.
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            The Distributed Lag Between Capital Appropriations and Expenditures

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              Generalized additive distributed lag models: quantifying mortality displacement.

              There are a number of applied settings where a response is measured repeatedly over time, and the impact of a stimulus at one time is distributed over several subsequent response measures. In the motivating application the stimulus is an air pollutant such as airborne particulate matter and the response is mortality. However, several other variables (e.g. daily temperature) impact the response in a possibly non-linear fashion. To quantify the effect of the stimulus in the presence of covariate data we combine two established regression techniques: generalized additive models and distributed lag models. Generalized additive models extend multiple linear regression by allowing for continuous covariates to be modeled as smooth, but otherwise unspecified, functions. Distributed lag models aim to relate the outcome variable to lagged values of a time-dependent predictor in a parsimonious fashion. The resultant, which we call generalized additive distributed lag models, are seen to effectively quantify the so-called 'mortality displacement effect' in environmental epidemiology, as illustrated through air pollution/mortality data from Milan, Italy.
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                Author and article information

                Journal
                20 January 2018
                Article
                1801.06670
                39a2f895-e95b-4b48-afe6-e6ab935dfc5c

                http://arxiv.org/licenses/nonexclusive-distrib/1.0/

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