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      Improving patient safety and efficiency of medication reconciliation through the development and adoption of a computer-assisted tool with automated electronic integration of population-based community drug data: the RightRx project

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          Abstract

          Background and Objective

          Many countries require hospitals to implement medication reconciliation for accreditation, but the process is resource-intensive, thus adherence is poor. We report on the impact of prepopulating and aligning community and hospital drug lists with data from population-based and hospital-based drug information systems to reduce workload and enhance adoption and use of an e-medication reconciliation application, RightRx.

          Methods

          The prototype e-medical reconciliation web-based software was developed for a cluster-randomized trial at the McGill University Health Centre. User-centered design and agile development processes were used to develop features intended to enhance adoption, safety, and efficiency. RightRx was implemented in medical and surgical wards, with support and training provided by unit champions and field staff. The time spent per professional using RightRx was measured, as well as the medication reconciliation completion rates in the intervention and control units during the first 20 months of the trial.

          Results

          Users identified required modifications to the application, including the need for dose-based prescribing, the role of the discharge physician in prescribing community-based medication, and access to the rationale for medication decisions made during hospitalization. In the intervention units, both physicians and pharmacists were involved in discharge reconciliation, for 96.1% and 71.9% of patients, respectively. Medication reconciliation was completed for 80.7% (surgery) to 96.0% (medicine) of patients in the intervention units, and 0.7% (surgery) to 82.7% of patients in the control units. The odds of completing medication reconciliation were 9 times greater in the intervention compared to control units (odds ratio: 9.0, 95% confidence interval, 7.4-10.9, P < .0001) after adjusting for differences in patient characteristics.

          Conclusion

          High rates of medication reconciliation completion were achieved with automated prepopulation and alignment of community and hospital medication lists.

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          Most cited references36

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          Public Health Surveillance Systems: Recent Advances in Their Use and Evaluation

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            A decade of agile methodologies: Towards explaining agile software development

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              Association of ICU or hospital admission with unintentional discontinuation of medications for chronic diseases.

              Patients discharged from acute care hospitals may be at risk for unintentional discontinuation of medications prescribed for chronic diseases. The intensive care unit (ICU) may pose an even greater risk because of the focus on acute events and the presence of multiple transitions in care. To evaluate rates of potentially unintentional discontinuation of medications following hospital or ICU admission. A population-based cohort study using administrative records from 1997 to 2009 of all hospitalizations and outpatient prescriptions in Ontario, Canada; it included 396,380 patients aged 66 years or older with continuous use of at least 1 of 5 evidence-based medication groups prescribed for long-term use: (1) statins, (2) antiplatelet/anticoagulant agents, (3) levothyroxine, (4) respiratory inhalers, and (5) gastric acid-suppressing drugs. Rates of medication discontinuation were compared across 3 groups: patients admitted to the ICU, patients hospitalized without ICU admission, and nonhospitalized patients (controls). Odds ratios (ORs) were calculated and adjusted for patient demographics, clinical factors, and health services use. The primary outcome was failure to renew the prescription within 90 days after hospital discharge. Patients admitted to the hospital (n = 187,912) were more likely to experience potentially unintentional discontinuation of medications than controls (n = 208,468) across all medication groups examined. The adjusted ORs (AORs) ranged from 1.18 (95% CI, 1.14-1.23) for discontinuing levothyroxine in 12.3% of hospitalized patients (n = 6831) vs 11.0% of controls (n = 7114) to an AOR of 1.86 (95% CI, 1.77-1.97) for discontinuing antiplatelet/anticoagulant agents in 19.4% of hospitalized patients (n = 5564) vs 11.8% of controls (n = 2535). With ICU exposure, the AORs ranged from 1.48 (95% CI, 1.39-1.57) for discontinuing statins in 14.6% of ICU patients (n = 1484) to an AOR of 2.31 (95% CI, 2.07-2.57) for discontinuing antiplatelet/anticoagulant agents in 22.8% of ICU patients (n = 522) vs the control group. Admission to an ICU was associated with an additional risk of medication discontinuation in 4 of 5 medication groups vs hospitalizations without an ICU admission. One-year follow-up of patients who discontinued medications showed an elevated AOR for the secondary composite outcome of death, emergency department visit, or emergent hospitalization of 1.07 (95% CI, 1.03-1.11) in the statins group and of 1.10 (95% CI, 1.03-1.16) in the antiplatelet/anticoagulant agents group. Patients prescribed medications for chronic diseases were at risk for potentially unintentional discontinuation after hospital admission. Admission to the ICU was generally associated with an even higher risk of medication discontinuation.
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                Author and article information

                Journal
                J Am Med Inform Assoc
                J Am Med Inform Assoc
                jamia
                Journal of the American Medical Informatics Association : JAMIA
                Oxford University Press
                1067-5027
                1527-974X
                May 2018
                11 October 2017
                11 October 2017
                : 25
                : 5
                : 482-495
                Affiliations
                [1 ]Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montréal, Canada
                [2 ]Department of Medicine, McGill University, Montréal, Canada
                [3 ]Clinical and Health Informatics Research Group, McGill University, Montréal, Canada
                [4 ]McGill University Health Centre, Montréal, Canada
                [5 ]Centre de Recherche du Centre Hospitalier de l'Université de Montréal, School of Public Health, University of Montréal, Montréal, Canada
                [6 ]The Research Institute of the McGill University Health Centre, Montréal, Canada
                [7 ]Division of Geriatric Medicine, University of Ottawa, Ottawa, Canada
                Author notes
                All correspondence addressed to: Robyn Tamblyn, 1140 Pine Ave. W, Montréal, QC H3A 1A3, Canada. Tel: 514-843-2831.
                Article
                ocx107
                10.1093/jamia/ocx107
                6018649
                29040609
                3ae99f3f-fb4b-4207-9a36-a28dd53a62e5
                © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

                History
                : 24 March 2017
                : 17 July 2017
                : 8 September 2017
                Page count
                Pages: 14
                Categories
                Research and Applications

                Bioinformatics & Computational biology
                medication reconciliation,medical informatics,medication systems,patient safety

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