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Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease.
Jochen Maul
1 ,
Christoph Loddenkemper ,
Pamela Mundt ,
Erika Berg ,
Thomas Giese ,
Andreas Stallmach ,
Martin Zeitz ,
Rainer Duchmann
Jun 2005
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Abstract
Regulatory CD25+ T cells (T(reg)) are effective in the prevention and down-regulation of inflammatory bowel disease (IBD) in animal models. Functional T(reg) cells are characterized by the expression of the transcription factor FOXP3 and show a CD4+ CD25(high) phenotype in humans. The aim of this study was to determine whether disease activity in IBD correlates with changes in frequency of T(reg) cells and their distribution in the intestinal mucosa.