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      The derivatization and antitumor mechanisms of polysaccharides

      Author(s): 1 , 2
      Publication date Created:
      Publication date (Print):
      Journal: Future Medicinal Chemistry
      Publisher: Future Science Ltd

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          Abstract

          At present, the polysaccharide antitumor research is focused on how to further improve the antitumor activity of polysaccharides. The structural modification of polysaccharides can enhance their antitumor activity to a certain extent. The antitumor mechanisms of polysaccharide derivatives mainly contain the inducing apoptosis of tumor cells, effecting on the cycle of tumor cells, enhancing the antioxidant activity of organism, activating the body's immune response and inhibiting the tumor angiogenesis. Herein, the common methods of polysaccharide modification, such as sulfation, carboxymethylation, phosphorylation and acetylation, were summarized. At the same time, the effects of chemical modification of polysaccharides on their antitumor mechanisms and activity were analyzed and discussed.

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          Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.

          Isaac Marin-Valencia, Chendong Yang, Tomoyuki Mashimo … (2012)
          Dysregulated metabolism is a hallmark of cancer cell lines, but little is known about the fate of glucose and other nutrients in tumors growing in their native microenvironment. To study tumor metabolism in vivo, we used an orthotopic mouse model of primary human glioblastoma (GBM). We infused (13)C-labeled nutrients into mice bearing three independent GBM lines, each with a distinct set of mutations. All three lines displayed glycolysis, as expected for aggressive tumors. They also displayed unexpected metabolic complexity, oxidizing glucose via pyruvate dehydrogenase and the citric acid cycle, and using glucose to supply anaplerosis and other biosynthetic activities. Comparing the tumors to surrounding brain revealed obvious metabolic differences, notably the accumulation of a large glutamine pool within the tumors. Many of these same activities were conserved in cells cultured ex vivo from the tumors. Thus GBM cells utilize mitochondrial glucose oxidation during aggressive tumor growth in vivo. Copyright © 2012 Elsevier Inc. All rights reserved.
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            Biological activities of sulfated polysaccharides from tropical seaweeds.

            L.S. Costa, G.P. Fidelis, S.L. Cordeiro … (2010)
            Sulfated polysaccharides from 11 species of tropical marine algae (one edible specie of Rhodophyta, six species of Phaeophyta and four species of Chlorophyta) collected from Natal city coast (Northeast of Brazil) were evaluated for their anticoagulant, antioxidant and antiproliverative in vitro activities. In the activated partial thromboplastin time (APTT) test, which evaluates the intrinsic coagulation pathway, seven seaweeds presented anticoagulant activity. Dictyota cervicornis showed the highest activity, prolonging the coagulation time to double the baseline value in the APTT with only 0.01 mg/100 microl of plasma, 1.4-fold lesser than Clexane, a low molecular weight heparin. In the protrombin time (PT) test, which evaluates the extrinsic coagulation pathway, only Caulerpa cupresoides showed anticoagulant activity. All species collected showed antioxidant activities. This screening emphasized the great antioxidant potential (total capacity antioxidant, power reducing and ferrous chelating) of four species: C. sertularioide; Dictyota cervicornis; Sargassum filipendula and Dictyopteris delicatula. After 72 h incubation, HeLa cell proliferation was inhibited (p<0.05) between 33.0 and 67.5% by S. filipendula; 31.4 and 65.7% by D. delicatula; 36.3 and 58.4% by Caulerpa prolifera and 40.2 and 61.0% by Dictyota menstrualis at 0.01-2mg/mL algal polysaccharides. The antiproliferative efficacy of these algal polysaccharides were positively correlated with the sulfate content (r=0.934). Several polysaccharides demonstrated promising antioxidant, antiproliferative an/or anticoagulant potential and have been selected for further studies on bioguided fractionation, isolation and characterization of pure polysaccharides from these species as well as in vivo experiments are needed and are already in progress. Copyright 2009 Elsevier Masson SAS. All rights reserved.
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              Antitumor activity of mushroom polysaccharides: a review.

              Yacine Hemar, Conrad O Perera, Lu Ren (2012)
              Mushrooms were considered as a special delicacy by early civilizations and valued as a credible source of nutrients including considerable amounts of dietary fiber, minerals, and vitamins (in particularly, vitamin D). Mushrooms are also recognized as functional foods for their bioactive compounds offer huge beneficial impacts on human health. One of those potent bioactives is β-glucan, comprising a backbone of glucose residues linked by β-(1→3)-glycosidic bonds with attached β-(1→6) branch points, which exhibits antitumor and immunostimulating properties. The commercial pharmaceutical products from this polysaccharide source, such as schizophyllan, lentinan, grifolan, PSP (polysaccharide-peptide complex) and PSK (polysaccharide-protein complex), have shown evident clinical results. The immunomodulating action of mushroom polysaccharides is to stimulate natural killer cells, T-cells, B-cells, neutrophils, and macrophage dependent immune system responses via differing receptors involving dectin-1, the toll-like receptor-2 (a class of proteins that play a role in the immune system), scavengers and lactosylceramides. β-Glucans with various structures present distinct affinities toward these receptors to trigger different host responses. Basically, their antitumor abilities are influenced by the molecular mass, branching configuration, conformation, and chemical modification of the polysaccharides. This review aims to integrate the information regarding nutritional, chemical and biological aspects of polysaccharides in mushrooms, which will possibly be employed to elucidate the correlation between their structural features and biological functions.
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                Author and article information

                Journal
                Title: Future Medicinal Chemistry
                Abbreviated Title: Future Medicinal Chemistry
                Publisher: Future Science Ltd
                ISSN (Print): 1756-8919
                ISSN (Electronic): 1756-8927
                Publication date Created: October 2017
                Publication date (Print): October 2017
                Volume: 9
                Issue: 16
                Pages: 1931-1938
                Affiliations
                [1 ]Active Carbohydrate Research Center, College of Chemistry, Chongqing Normal University, Chongqing 401331, China
                [2 ]School of Chemistry & Environmental Engineering, Wuhan Institute of Technology, Wuhan 430073, China
                Article
                DOI: 10.4155/fmc-2017-0132
                PubMed ID: 29076350
                SO-VID: 3f0dbdfb-ff8c-4bbb-a910-e8629121a8a8
                Copyright © © 2017
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