Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma

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Abstract

Angiogenesis is the growth of new capillaries from the preexisting blood vessels. Glioblastoma (GBM) tumors are highly vascularized tumors, and glioma growth depends on the formation of new blood vessels. Angiogenesis is a complex process involving proliferation, migration, and differentiation of vascular endothelial cells (ECs) under the stimulation of specific signals. It is controlled by the balance between its promoting and inhibiting factors. Various angiogenic factors and genes have been identified that stimulate glioma angiogenesis. Therefore, attention has been directed to anti-angiogenesis therapy in which glioma proliferation is inhibited by inhibiting the formation of new tumor vessels using angiogenesis inhibitory factors and drugs. Here, in this review, we highlight and summarize the various molecular mediators that regulate GBM angiogenesis with focus on recent clinical research on the potential of exploiting angiogenic pathways as a strategy in the treatment of GBM patients.

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Author and article information

Contributors

Sajani S. Lakka:

ORCID: http://orcid.org/0000-0002-8786-5626

slakka@uic.edu

Journal

Journal ID (nlm-ta): Mol Neurobiol

Journal ID (iso-abbrev): Mol. Neurobiol

Title: Molecular Neurobiology

Publisher: Springer US (New York )

ISSN (Print): 0893-7648

ISSN (Electronic): 1559-1182

Publication date (Electronic): 9 March 2020

Publication date PMC-release: 9 March 2020

Publication date (Print): 2020

Volume: 57

Issue: 5

Pages: 2461-2478

Affiliations

[1 ]GRID grid.185648.6, ISNI 0000 0001 2175 0319, Section of Hematology and Oncology, , University of Illinois College of Medicine at Chicago, ; Chicago, IL 60612 USA

[2 ]GRID grid.185648.6, ISNI 0000 0001 2175 0319, Department of Neurosurgery, , University of Illinois College of Medicine at Chicago, ; Chicago, IL 60612 USA

Author information

Sajani S. Lakka http://orcid.org/0000-0002-8786-5626

Article

Publisher ID: 1892

DOI: 10.1007/s12035-020-01892-8

PMC ID: 7170819

PubMed ID: 32152825

SO-VID: 3f20885d-c5e9-4e90-87dd-3a7d250a009c

License:

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

History

Date received : 1 September 2019

Date accepted : 14 February 2020

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ScienceOpen disciplines: Neurosciences

Keywords: angiogenesis,anti-angiogenesis therapy,glioblastoma (gbm),clinical trials in glioblastoma (gbm),tumor development

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ScienceOpen disciplines: Neurosciences

Keywords: angiogenesis, anti-angiogenesis therapy, glioblastoma (gbm), clinical trials in glioblastoma (gbm), tumor development

Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma

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Neuronal Signaling

Most cited references 137

Angiogenesis in life, disease and medicine.

Drug resistance and the solid tumor microenvironment.

Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry.

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