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Abstract
Correction to: J Transl Med (2018) 16:3 10.1186/s12967-017-1378-2
Following publication of the original article [1], the authors reported that they
omitted to state that parts of Fig. 2 were adapted from Van Acker et al. [2] published
by Taylor & Francis Ltd (www.tandfonline.com). The authors apologise for this omission.
Figure 2 and its corrected caption are given below.
Fig. 2
Antitumor and protumor functions of γδ T cells. γδ T cells have both direct and indirect
antitumor effects. Direct antitumor effects are mediated by lysing the tumor through
the perforin-granzyme pathway, providing an early source of the inflammatory cytokines
such as IFN-γ and TNF-α, eliminating Fas+ and TRAIL-R+ tumor cells, and ADCC. The
indirect antitumor role of γδ T cells is mediated by polarized γδ Tfh cells, which
promote B-cell antibody secretion. Besides, γδ T cells also present antigens for αβ
T cell priming, trigger dendritic cell (DC) maturation, and induce robust NK cell-mediated
antitumor cytotoxicity to play indirect antitumor role. With regard to their protumor
effect, γδ T cells can polarize into FOXP3+ γδ Treg cells, and γδ T17 cells. In addition,
Vδ1 T cells are another subset of γδ T cells that possess protumor activity. γδ T
cells are able to directly impair αβ T cells and DC antitumor immunocyte function.
γδ T cells can also enhance MDSC, SPM, and neutrophil immunosuppressive functions.
Together, these actions promote tumor angiogenesis, growth, proliferation, metastasis,
and immune escape
(Parts of this figure are adapted from Van Acker et al.)
Gamma delta (γδ) T cells are the all-rounders of our immune-system with their major histocompatibility complex-unrestricted cytotoxicity, capacity to secrete immunosti-mulatory cytokines and ability to promote the generation of tumor antigen-specific CD8+ and CD4+ T cell responses. Dendritic cell (DC)-based vaccine therapy has the prospective to harness these unique features of the γδ T cells in the fight against cancer. In this review, we will discuss our current knowledge on DC-mediated γδ T cell activation and related opportunities for tumor immunologists.
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